锦鸡儿属植物抗炎活性成分与抗炎作用和机制研究进展  

Progress in the study of anti-inflammatory active components with anti-inflammatory effects and mechanisms in Caragana Fabr.

作　　者：马玉梅 罗菊元 陈涛[1] 李洪梅[1,3] 申诚 王硕 宋志博[1,3] 李玉林 MA Yu-mei;LUO Ju-yuan;CHEN Tao;LI Hong-mei;SHEN Cheng;WANG Shuo;SONG Zhi-bo;LI Yu-lin(Northwest Institute of Plateau Biology,Chinese Academy of Sciences,Xining 810008,China;Qinghai Institute of Health Sciences,Xining 810000,China;University of Chinese Academy of Sciences,Beijing 100049,China)

机构地区：[1]中国科学院西北高原生物研究所,青海西宁810008 [2]青海卫生职业技术学院,青海西宁810000 [3]中国科学院大学,北京100049

出　　处：《药学学报》2025年第1期58-71,共14页Acta Pharmaceutica Sinica

基　　金：青海省重点研发与转化计划项目(2023-SF-112);青海省卫生健康系统指导性计划课题(2021-wjzdx-112)。

摘　　要：锦鸡儿属(Caragana Fabr.)是豆科荒漠植物,在传统民族医药中应用广泛,具有滋阴养血、祛风除湿、清热解毒之功效。锦鸡儿属植物的抗炎作用备受关注,相关机制研究取得一定进展,但是目前没有任何文献对该属植物的抗炎成分及抗炎作用进行综述。本文通过对锦鸡儿属活性成分的抗炎作用进行总结,发现其对体外不同炎症细胞模型有很好的抗炎活性,且对类风湿性关节炎、结肠炎、复合型肾炎和急性肺损伤等疾病模型均具有较好的改善作用。该属植物活性成分抗炎作用主要包括降低多种促炎因子水平,涉及到的信号通路主要包括TLR4/NF-κB、TLR4/MAPK、TLR4/NF-κB/IRF3、JAK/STAT-1、ERK/STAT-1等。因此,该文主要对锦鸡儿属植物及其活性成分的抗炎作用与机制研究进展按疾病种类进行综述,以期为其抗炎活性的深入研究及相关功能新产品的开发提供参考。The plants of the genus Caragana Fabr.are desert plants of the Leguminosae family,which are widely used in traditional ethnomedicine,with the effects of nourishing Yin and nourishing blood,dispelling wind and removing dampness,clearing heat and detoxifying toxins.The anti-inflammatory effect of Caragana Fabr.has attracted much attention,the research on the related mechanism has made some progress,but it lacks systematic collation.By summarising the anti-inflammatory effects of the active ingredients of Caragana Fabr.,the authors found that they havegood anti-inflammatory activities on different inflammatory cell models in vitro,and have good improvementeffects on rheumatoid arthritis,colitis,complex nephritis,and acute lung injury and otherdisease models.The anti-inflammatory effects of the active components of this genus mainly includethe reduction of the levels of a variety of pro-inflammatory factors,and the signalling pathways involvedmainly include TLR4/NF-κB,TLR4/MAPK,TLR4/NF-κB/IRF3,JAK/STAT-1,ERK/STAT-1and so on.Therefore,the paper mainly reviews the research progress on the anti-inflammatory effectsand mechanisms of the Caragana Fabr.plants and their active components according to diseasetypes,with a view to providing reference for the in-depth study of their anti-inflammatory activitiesand the development of new products with related functions.

关 键 词：锦鸡儿属 活性成分 抗炎作用与机制 

分 类 号：R284[医药卫生—中药学]