口服远处靶向纳米递送系统的研究进展  

Advances in oral distant targeted nanodelivery systems

作　　者：孙敏[1,2] 黄川生 王立萍 阮徐莉[2] 赵云丽 王新春 SUN Min;HUANG Chuan-sheng;WANG Li-ping;RUAN Xu-li;ZHAO Yun-li;WANG Xin-chun(The First Affiliated Hospital of Shihezi University,Shihezi 832061,China;School of Pharmacy,Shihezi University,Shihezi 832061,China)

机构地区：[1]石河子大学第一附属医院,新疆石河子832061 [2]石河子大学药学院,新疆石河子832061

出　　处：《药学学报》2025年第1期72-81,共10页Acta Pharmaceutica Sinica

基　　金：兵团财政科技计划项目(2022AB020,2023AB045)。

摘　　要：由于患者的依从性和方便性,口服给药可能是最常用和最可接受的给药途径。然而,传统的给药剂型,如片剂或胶囊制剂,可能导致药物的生物利用度低和治疗效率差。因此,随着材料科学和微纳米制造技术的发展,各种载体被开发出来以保护和提高药物在胃肠道的吸收。在此,首先讨论了阻碍药物运输和吸收的主要生理因素(各种解剖学因素、物理因素和生化因素);在此基础上,综述了近年来提高药物生物利用度和靶向性的传统和新型口服给药途径的研究进展;最后,展望了口服药物输送系统的未来前景及临床转化的潜在挑战。Due to patient compliance and convenience,oral medication is likely the most common and acceptable method of drug administration.However,traditional dosage forms such as tablets or capsules may lead to low drug bioavailability and poor therapeutic efficiency.Therefore,with advancements in material science and micro/nano manufacturing technology,various carriers have been developed to enhance drug absorption in the gastrointestinal tract.In this context,we initially discuss the key biological factors that hinder drug transport and absorption(including anatomical,physical,and biological factors).Building on this foundation,recent progress in both conventional and innovative oral drug delivery routes aimed at improving drug bioavailability and targeting is reviewed.Finally,we explore future prospects for oral drug delivery systems as well as potential challenges in clinical translation.

关 键 词：口服给药系统 胃肠道 生理障碍 口服靶向 口服纳米药物 

分 类 号：R943[医药卫生—药剂学]