羊角棉中1个新的糖苷类化合物  

A new glycoside from Alstonia mairei Lévl.

作　　者：王立柯 李冰燕 赵珍珠 王彦志[1,2] 李晓坤 冯卫生[1,2] 司盈盈 WANG Li-ke;LI Bing-yan;ZHAO Zhen-zhu;WANG Yan-zhi;LI Xiao-kun;FENG Wei-sheng;SI Ying-ying(School of Pharmacy,Henan University of Traditional Chinese Medicine,Zhengzhou 450046,China;Engineering and Technology Center for Chinese Medicine Development of Henan Province,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学药学院,河南郑州450046 [2]河南省中药开发工程技术研究中心,河南郑州450046

出　　处：《药学学报》2025年第1期191-195,共5页Acta Pharmaceutica Sinica

基　　金：河南省科技攻关项目(232102310383);河南省高校科技创新团队支持计划资助(24IRTSTHN039)。

摘　　要：利用硅胶、Sephadex LH-20、MCI Gel和ODS等柱色谱,结合半制备液相等分离方法,从羊角棉90%乙醇提取物中分离纯化得到9个化合物。运用现代波谱学方法(1D和2D NMR、UV、IR、MS等)对所分离得到的化合物进行结构鉴定,分别鉴定为mairoside A(1)、3′,6-二-O-芥子酰基蔗糖(2)、肉豆蔻醚酸(3)、肉豆蔻醚酸甲酯(4)、肉豆蔻醚酸乙酯(5)、3,4,5-三甲氧基桂皮酸(6)、3,4,5-三甲氧基苯甲酸(7)、维诺林(8)、山柰酚-3-O-芸香糖苷(9),其中化合物1为新糖苷类化合物,化合物4和5为新天然产物,且化合物4的核磁数据为首次报道。Nine compounds were isolated and purified from 90%ethanol extract of Alstonia mairei Lévl by using various chromatographic methods,including silica gel,SephadexLH-20,MCI Gel and ODS column chromatography,combined with semi-preparative liquid phase separation methods.Modern spectroscopic methods(ID and 2D NMR,UV,IR,MS,etc.)were used to identify the structures of the isolated compounds.They were identified as mairoside A(1),3',6-di-O-sinaloylsucrose(2),myristic acid(3),methyl myristate(4),ethyl myristate(5),3,4,5-trimethoxycinnamic acid(6),3,4,5-trimethoxybenzoic acid(7),vinoline(8),kaempferol-3-O-rutinoside(9),among which compound 1 is a new glycoside,compounds 4 and 5 are new natural products,and the nuclear magnetic data of compound 4 were reported for the first time.

关 键 词：鸡骨常山属 羊角棉 化学成分 糖苷 分离鉴定 

分 类 号：R284[医药卫生—中药学]