ECMO设备血液流量主要影响因素的研究  

Research on the Main Influencing Factors of ECMO Flow Rate

作　　者：蔡海青 许朝生 吴少海[1,2] CAI Haiqing;XU Chaosheng;WU Shaohai(Guangdong Medical Devices Quanlity Surveillance and Testing Institute,Guangzhou Guangdong 510663,China;NMPA Key Laboratory of Extracorporeal Circulation Devices,Guangzhou Guangdong 510663,China)

机构地区：[1]广东省医疗器械质量监督检验所,广东广州510663 [2]国家药品监督管理局体外循环器械重点实验室,广东广州510663

出　　处：《中国医疗设备》2025年第2期29-34,共6页China Medical Devices

基　　金：广东省药品监督管理局科技创新项目(2023ZDZ09)。

摘　　要：目的通过模拟试验方式,研究影响ECMO设备血液流量的主要因素。方法设计3个试验:试验一,在不同转速下,测量静态泵后管路压力范围为70~130 mmHg时的血流量,并计算分析静态泵后管路压力与血流量的相关系数;试验二,在不同转速下,分别用1∶3、2∶3及3∶3比例的甘油/生理盐水混合液模拟不同试验的介质黏度,并测量分析血液流量与试验介质黏度的相关系数;试验三,设计不同的试验模型(患者端的模拟),在相同转速下与试验一、二对比试验差异。通过3个试验研究影响ECMO设备血液流量的主要因素。结果试验发现,静态泵后管路压力与流量显示值、流量实测值和流量误差的相关系数分别为0.49~0.93、0.11~0.70和0.26~0.89,相关性不强,而甘油/生理盐水的比例与流量呈强负相关,相关系数为-1.000~-0.961。另外,不同的患者端模拟模型也会对血液流量造成影响。结论泵前后压差以及试验介质的黏稠度是影响ECMO设备血液流量的主要因素,但静态泵后管路压力对ECMO设备血液流量影响不明显。Objective To study the main factors affecting the blood flow of ECMO equipment through simulation test.Methods Three experiments were designed.In experiment 1,the blood flow was measured when the pipeline pressure range was 70-130 mmHg at different rotational speeds,and the correlation coefficient between the pipeline pressure and the blood flow was calculated and analyzed.In experiment 2,glycerol/saline mixtures at 1∶3,2∶3 and 3∶3 ratios were used to simulate the viscosity of different tests,and the correlation coefficients between blood flow and viscosity of test media were measured and analyzed.In experiment 3,different test models(patient-side simulation)were designed and compared with experiments 1 and 2 at the same speed.Three experiments were conducted to study the main factors influencing the blood flow of ECMO equipment.Results It was found that the correlation coefficients between the pipeline pressure and the displayed flow value,the measured flow value and the flow error after the static pump were 0.49 to 0.93,0.11 to 0.70 and 0.26 to 0.89,respectively,and the correlation coefficients were strong negative correlation between the glycerol/saline ratio and the flow rate,and the correlation coefficient was-1.000 to-0.961.In addition,different patient-side simulation models also have an impact on blood flow.Conclusion The pressure difference before and after the pump and the viscosity of the test medium are the main factors affecting the blood flow of ECMO equipment,but the pipeline pressure after the static pump has no obvious effect on the blood flow of ECMO equipment.

关 键 词：ECMO 血液流量 离心泵 心肺转流系统 体外心肺支持辅助设备 管路压力 黏度 

分 类 号：R197.39[医药卫生—卫生事业管理]