肌酸激酶总胆红素与α-羟丁酸脱氢酶在新生儿溶血病筛查中检测意义与价值分析  

Analysis of the significance and value of creatine kinase,total bilirubin andα-hydroxybutyrate dehydrogenase detection in the screening of hemolytic disease of newborns

作　　者：梁丹 Liang Dan(Blood Transfusion Department,Xinyang People′s Hospital,Xinyang 464000,China)

机构地区：[1]信阳市人民医院输血科,信阳464000

出　　处：《实用医技杂志》2025年第1期54-57,共4页Journal of Practical Medical Techniques

摘　　要：目的探讨肌酸激酶(CK)、总胆红素(TBIL)与α-羟丁酸脱氢酶(α-HBD)在新生儿溶血病(HDN)筛查中检测意义与价值。方法择取2021年1月至2023年12月80例新生儿HDN设为研究组,另选择同时期80例非HDN新生儿作为对照组。检测各组的TBIL、直接胆红素(DBIL)、间接胆红素(IBIL)、心肌酶谱[天冬氨酸转氨酶(AST)、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)、α-HBD];分析各指标与HDN之间的相关性。结果对照组TBIL[(92.2±2.2)μmol/L与(209.9±12.3)μmol/L,t=-84.599,P<0.001]、DBIL[(11.3±2.9)μmol/L与(15.2±3.3)μmol/L,t=-8.068,P<0.001]及IBIL[(80.5±13.0)μmol/L与(180.3±23.2)μmol/L,t=-33.589,P<0.001]的浓度上低于研究组,差异具有统计学意义。对照组AST[(30.2±7.3)U/L与(45.3±9.2)U/L,t=-11.448,P<0.001]、CK-MB[(35.1±8.5)U/L与(48.3±4.6)U/L,t=-12.257,P<0.001]、LDH[(265.0±24.2)U/L与(405.6±19.9)U/L,t=-40.199,P<0.001]、CK[(73.6±12.1)U/L与(384.6±29.5)U/L,t=-87.307,P<0.001]、α-HBD[(220.64±48.19)U/L与(384.56±35.57)U/L,t=-24.478,P<0.001]的水平低于研究组,差异具有统计学意义。AST、LDH与TBIL无相关性(P>0.05);CK-MB(r=-0.851,P<0.001)、CK(r=-0.792,P<0.001)与TBIL均呈负相关。α-HBD与TBIL呈正相关(r=0.461,P=0.002)。结论HDN患儿存在CK、TBIL与a-HBD的改变,提示患儿可能存在心功能与神经系统功能损伤,但与HDN无明显线性相关性。Objective To investigate the significance and value of creatine kinase(CK),total bilirubin(TBIL)andα-hydroxybutyrate dehydrogenase(α-HBD)in neonatal hemolytic disease(HDN)screening.Methods A total of 80 HDN neonates from January 2021 to December 2023 were selected as the study group,and 80 non-HDN neonates were selected as the control group.The TBIL,direct bilirubin(DBIL),indirect bilirubin(IBIL)and myocardial enzyme profiles of aspartate amino converting enzyme(AST),CK,phosphocreatine kinase isoenzyme(CK-MB),lactate dehydrogenase(LDH),α-hydroxybutyrate dehydrogenase(α-HBD)were detected in each group.The correlation between each index and HDN was analyzed.Results In the control group,TBIL[(92.2±2.2)μmol/L and(209.9±12.3)μmol/L,t=-84.599,P<0.001],DBIL[(11.2±2.9)μmol/L and(15.2±3.3)μmol/L,t=-8.068,P<0.001]and IBIL[(80.5±13.0)μmol/L and(180.3±23.2)μmol/L,t=-33.589,P<0.001]were lower than those of the study group,and the differences were statistically significant.Control group AST[(30.3±7.3)U/L and(45.3±9.2)U/L,t=-11.448,P<0.001],CK-MB[(35.1±8.5)U/L and(48.3±4.6)U/L,t=-12.257,P<0.001],LDH[(265.0±24.2)U/L and(405.6±19.9)U/L,t=-40.199,P<0.001],CK[(73.6±12.1)U/L and(384.6±29.5)U/L,t=-87.307,P<0.001]andα-HBD[220.64±48.19 U/L and 384.56±35.57 U/L,t=-24.478,P<0.001]in the control group were lower than those of the study group,and the difference was statistically significant.AST,LDH and TBIL were not correlated(P>0.05).CK-b MB(r=-0.851,P<0.001)and CK(r=-0.792,P<0.001)were negatively correlated with TBIL.α-HBD was positively correlated with TBIL(r=0.461,P=0.002).Conclusion There are CK,TBIL andα-HBD changes in children with HDN,suggesting that the children may have cardiac and nervous system function impairment,but there is no obvious linear correlation with HDN.

关 键 词：肌酸激酶 总胆红素 a-羟丁酸脱氢酶 溶血病 

分 类 号：R722.18[医药卫生—儿科]