N,N′-二芳基甲脒的合成研究进展  

Research Progress on the Synthesis of N,N′-Diarylformamidines

作　　者：张静怡 李佳颖 赵晋 李云鹤 孙保龙 ZHANG Jingyi;LI Jiaying;ZHAO Jin;LI Yunhe;SUN Baolong(College of Chemistry and Chemical Engineering,Zhengzhou Normal University,Zhengzhou Henan 450044,China)

机构地区：[1]郑州师范学院化学化工学院,河南郑州450044

出　　处：《广州化工》2025年第3期14-16,共3页GuangZhou Chemical Industry

基　　金：郑州师范学院大学创新创业训练计划项目(DCY2024037)。

摘　　要：N,N′-二芳基甲脒是一类重要的有机化合物,它们具有独特的化学性质和生物活性,使其广泛应用于药物化学、材料科学和有机合成领域。近年来,N,N′-二芳基甲脒的合成研究取得了显著进展,开发了多种高效、绿色的合成方法。例如,通过过渡金属催化的偶联反应或无金属条件下的直接反应,可以实现高产率的合成。本文综述了这些合成方法,并从反应策略上对反应进行总结、归纳及分析。此外,还将对该反应的发展做出展望,探讨未来可能的研究方向和应用前景。通过对N,N′-二芳基甲脒合成的全面综述,旨在为研究人员提供有价值的参考资料,以推动该领域的进一步发展。N,N′-diarylformamidines represent a crucial class of organic compounds renowned for their distinctive chemical properties and biological activities,rendering them extensively employed in medicinal chemistry,materials science,and organic synthesis.In recent years,remarkable advancements have been achieved in the synthesis of N,N′-diarylformamidines through the development of diverse efficient and environmentally friendly synthetic methodologies.For instance,high-yield synthesis can be accomplished via transition metal-catalyzed coupling reactions or direct reactions conducted under metal-free conditions.This review article comprehensively examined these synthetic approaches while strategically summarizing and analyzing the reactions.Furthermore,it explores potential research directions and application prospects to discuss the future development of these reactions.By providing valuable reference material for researchers through an extensive review on N,N′-diarylformamidine synthesis,this paper aims to promote further progress in this field.

关 键 词：甲脒 芳基 苯胺 合成 

分 类 号：O622.6[理学—有机化学]