老年衰弱与系统免疫炎症指数、多病共存的相关性研究  

The correlation between frailty and systemic immune inflammatory index(SII)and multimorbidity in old patients

作　　者：童嫘 雒虹郦 梁晓莹 金明磊[2] 杨阳[2] TONG Lei;LUO Hongli;LIANG Xiaoying;JIN Minglei;YANG Yang(Chengde Medical University,Chengde 067000;The central hospital in Chengde,Chengde 067000,China)

机构地区：[1]承德医学院,067000 [2]承德市中心医院,067000

出　　处：《中国老年保健医学》2024年第6期10-13,共4页Chinese Journal of Geriatric Care

基　　金：承德市科技支撑计划项目(编号:202002A009)。

摘　　要：目的探讨系统免疫炎症指数(SII)、多病共存与老年衰弱的相关性分析。方法收集承德市中心医院老年病科患者共294例,根据FRAIL衰弱筛查量表进行评分,并根据评分将患者分为衰弱组及非衰弱组。收集患者的一般资料,包括年龄、性别、体质量指数等,以及生化指标,包括白细胞计数、红细胞计数、血小板计数、血红蛋白、人血白蛋白、血清丙氨酸氨基转移酶、血清天冬氨酸氨基转移酶、甘油三酯、总胆固醇、低密度脂蛋白胆固醇等,计算得到SII。收集患者既往病史,计算得查尔森共病指数。分析比较两组间的差异,探索衰弱发生的影响因素。结果收集的294例患者中,非衰弱组患者195例(66.3%),衰弱组患者99例(33.7%)。两组间年龄、SII、查尔森共病指数、中性粒细胞计数、白蛋白、ALT、总胆固醇、红细胞计数、血红蛋白差异有统计学意义(P<0.05),在除外共线性因素后,年龄、SII、查尔森共病指数与老年衰弱呈正相关(P<0.05)。年龄、SII、查尔森共病指数是老年患者衰弱发生的危险因素。结论老年住院患者衰弱的发生与年龄、SII、多病共存相关,年龄、SII、多病共存是衰弱发生的影响因素。Objective To explore the correlation between frailty and systemic immune inflammatory index(SII)and multimorbid-ity in old patients.Methods A total of 294 old patients were collected from the central hospital in Chengde,which were divided into the non frail group and the frail group according to the on the FRAIL Scale.Collect the general information of patients,including age,gender,body mass index,and biochemical indicators,including white blood cell count,red blood cell count,platelet count,hemoglobin,albumin,alanine aminotransferase,aspartic aminotransferase,triglyceride,total cholesterol,low-density lipoprotein,etc.,and count the SII.Collect the anamnesis to count the Charlson Comorbidity Index.Analyze and compare the differences between the two groups and the influencing factors of frailty occurrence.Results Among the 294 patients collected,195 were in the non frail group(66.9%),and 99 were in the frail group(33.7%).There were significant differences in age,SII,the Charlson Comorbidity Index,neutrophil count,albumin,alanine aminotransferase,total cholesterol,red blood cell count,hemoglobin between the two groups(P<0.05).After excluding collinearity,age,SII and the Charlson Comorbidity Index were positively correlated with the occurrence of frailty(P<0.05).Age,SII and the Charlson Comorbidity Index are risk factors for the occurrence of frailty.Conclusion The occur-rence of frailty in old patients is related to age,SII,and multimorbidity,and they are influencing factors for the occurrence of frailty.

关 键 词：老年 衰弱 共病 系统免疫炎症指数 

分 类 号：R47[医药卫生—护理学]