丁苯酞联合康复训练治疗多系统萎缩的临床效果  

The clinical effects of combined therapy with butyrophenone and rehabilitation training on multiple system atrophy

作　　者：贾艳菊 臧璇 JIA Yanju;ZANG Xuan(Inner Mongolia International Mongolian Medical Hospital,Hohhot 010065,China)

机构地区：[1]内蒙古国际蒙医医院药学部,010065

出　　处：《中国老年保健医学》2024年第6期61-64,共4页Chinese Journal of Geriatric Care

摘　　要：目的运用丁苯酞联合康复训练治疗多系统萎缩,观察其临床效果。方法选取2020年5月至2022年10月在内蒙古国际蒙医医院脑病科就诊的多系统萎缩患者36例作为研究对象,将患者随机分成对照组和研究组。对照组仅接受传统基础药物治疗,研究组在传统基础药物治疗基础上应用丁苯酞联合康复训练疗法。使用统一的多系统萎缩评估量表(UMSARS)、蒙特利尔认知评估量表(MoCA)以及改良的Barthel指数(BI)对两组患者在治疗前后的大运动及自主神经功能、认知能力和日常生活能力进行评估,测定神经因子水平并观察其不良反应情况。结果研究组患者UMSARS评分低于对照组,MoCA评分和BI指数高于对照组,差异有统计学意义(P<0.05)。研究组患者脑源性神经营养因子(BDNF)水平高于对照组,S-100β蛋白(S-100β)水平低于对照组,差异有统计学意义(P<0.05),两组患者不良反应发生率无统计学差异(P>0.05)。结论丁苯酞联合康复运动治疗多系统萎缩的疗效显著,提高患者生存质量,值得临床推广应用。Objective The clinical effects of treating multiple system atrophy with butyrophenone combined with rehabilitation training were observed.Methods 36 patients with multiple system atrophy who visited the Department of Brain Disease at the Inner Mongolia International Mongolian Hospital from May 2020 to October 2022 were selected as the study subjects.The subjects were randomly assigned to a control group and a study group.The control group only received traditional basic drug treatment while the study group added butyrophenone combined with rehabilitation training on this basis.The Unified Multiple System Atrophy Assess-ment Scale(UMSARS),Montreal Cognitive Assessment Scale(MoCA),and modified Barthel Index(BI)were used to assess the mo-tor and autonomic nervous functions,cognitive abilities,and daily living abilities of the two groups of patients before and after treat-ment.The neurocyte levels were measured and their adverse reactions were observed.Results The research group's patients had a lower UMSARS score than the control group,while the MoCA score and BI index were higher than those of the control group,with sta-tistically significant differences(P<0.05).The level of brain-derived neurotrophic factor(BDNF)in the study group was higher than that in the control group,and the level of S-100βprotein(S-100β)was lower than that in the control group,with statistically signifi-cant differences(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The efficacy of butyrophenone combined with rehabilitation exercise treatment for multiple system atrophy is significant,improving the quality of life for patients,and it is worthy of clinical promotion and application.

关 键 词：神经系统变性病 多系统萎缩 丁苯酞 康复训练 

分 类 号：R47[医药卫生—护理学]