慢性阻塞性肺疾病合并阻塞性睡眠呼吸暂停的生物标志物研究进展  

Research progress on biomarkers for chronic obstructive pulmonary disease complicated with obstructive sleep apnea

作　　者：强士豪 戴晴霞 黄丽娜 郭华 崔小川 QIANG Shihao;DAI Qingxia;HUANG Lina;GUO Hua;CUI Xiaochuan(Department of General Medicine,the Affiliated Wuxi People’s Hospital of Nanjing Medical University,Wuxi 214023,China)

机构地区：[1]南京医科大学附属无锡人民医院全科医学科,江苏无锡214023

出　　处：《内科理论与实践》2024年第5期322-327,共6页Journal of Internal Medicine Concepts & Practice

基　　金：国家自然科学基金项目(82200106)。

摘　　要：阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)和慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)同时存在时被称为COPD⁃OSA重叠征,又称为重叠综合征(overlap syndrome,OS)。与单纯的OSA和COPD相比,OS患者的疾病负担更重,预后更差。由于肺功能及多导睡眠监测检查不能被广泛应用于患者,目前较多研究探讨与OS相关的免疫学、血细胞、基因蛋白、体液及其他相关的生物标志物在其辅助诊断、预测发病风险及疾病严重程度中的临床价值。本文针对目前OS相关生物学标志物的临床研究进展进行综述。The coexistence of obstructive sleep apnea(OSA)and chronic obstructive pulmonary disease(COPD)is referred to as COPD⁃OSA overlap,also known as overlap syndrome(OS).OS patients are more severe and have worse prognosis than those with OSA and COPD alone.Because pulmonary function and polysomnography cannot be conducted widely for patients,at present,there are many research to explore the clinical value of immunology,blood cell,gene protein,body fluid and other related biomarkers related to OS in assisting diagnosis,predicting the risk and severity of disease.This article reviews the recent research progress on OS⁃related biological markers.

关 键 词：重叠综合征 生物标志物 慢性阻塞性肺疾病 阻塞性睡眠呼吸暂停 

分 类 号：R563.5[医药卫生—呼吸系统]