神应养真汤治疗血虚风燥型脂溢性脱发  

Effect of Shen Ying Yang Zhen tang in the treatment of seborrheic alopecia with the syndrome of wind and dryness due to blood deficiency

作　　者：夏丽晔 汪文翠 尚智伟[1] XIA Liye;WANG Wencui;SHANG Zhiwei(Clinical Medicine School of Henan University of Science and Technology/First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471003,China)

机构地区：[1]河南科技大学临床医学院/河南科技大学第一附属医院,河南洛阳471003

出　　处：《吉林中医药》2025年第2期196-200,共5页Jilin Journal of Chinese Medicine

基　　金：河南省2023年科技发展计划项目(232102210028)。

摘　　要：目的探讨血虚风燥型脂溢性脱发(SA)患者采用神应养真汤进行治疗的临床疗效。方法研究对象选自于在河南科技大学第一附属医院接受治疗的血虚风燥型脂溢性脱发患者,纳入时间为2022年10月—2023年8月,共纳入60例,并按随机数表法分为对照组与治疗组,各30例。对照组采用米诺地尔酊治疗;治疗组在对照组基础上给予神应养真汤。2组均治疗6个月。比较2组治疗6个月后的临床疗效,治疗前、治疗6个月后的中医证候积分、血液流变学指标、微量元素、性激素及胰岛素样生长因子-I(IGF-I)、转化生长因子-β_(2)(TGF-β_(2))、肝细胞生长因子(HGF),治疗期间的安全性。结果治疗6个月后,治疗组总有效率高于对照组(93.33%vs 73.33%,P<0.05)。与治疗前比较,治疗6个月后,2组各项中医证候积分、血液流变学指标及血清睾酮(T)、TGF-β_(2)水平均降低,且相比于对照组,治疗组更低;2组头发中锌(Zn)、铜(Cu)、铁(Fe)、钙(Ca)及血清雌二醇(E2)、IGF-I、HGF水平均升高,且相比于对照组,治疗组更高(P<0.05)。治疗组和对照组治疗期间的不良反应发生率比较差异无统计学意义(20.00%vs 16.67%,P>0.05)。结论神应养真汤治疗血虚风燥型脂溢性脱发可有效缓解患者临床症状,改善患者血液流变学指标,并调节患者头发中微量元素、性激素及相关因子水平,进而提高疗效,且安全性良好。Objective To explore the clinical efficacy of Shen Ying Yang Zhen tang in the treatment of seborrheic alopecia(SA)with the syndrome of wind and dryness due to blood deficiency.Methods The research subjects were selected from the SA patients with the syndrome of wind and dryness due to blood deficiency who received treatment at the First Affiliated Hospital of Henan University of Science and Technology.The inclusion period was from October 2022 to August 2023,with a total of 60 cases included and randomly divided into a control group and a treatment group,with 30 cases in each group.The control group was treated with minoxidil tincture,while the treatment group was given Shen Ying Yang Zhen tang on the basis of the control group.Both groups were treated for 6 months.The clinical efficacy after 6 months of treatment,the TCM syndrome scores,hemorheological indicators,trace elements,sex hormones,insulin-like growth factor-I(IGF-I),transforming growth factor-β_(2)(TGF-β_(2))and hepatocyte growth factor(HGF)before and after 6 months of treatment,as well as the safety during the treatment period were compared between the two groups.Results After 6 months of treatment,the total effective rate of the treatment group was higher than that of the control group(93.33%vs 73.33%,P<0.05).Compared with before treatment,after 6 months of treatment,the scores of various TCM syndromes,the levels of hemorheological indicators,and serum testosterone(T)and TGF-β_(2)were decreased in both groups,and compared with the control group,the treatment group was much lower.The levels of zinc(Zn),copper(Cu),iron(Fe),calcium(Ca),serum estradiol(E2),IGF-I,and HGF were increased in both groups,and compared with the control group,the treatment group was much higher(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the treatment group and the control group during the treatment period(20.00%vs 16.67%,P>0.05).Conclusion In the treatment of SA with the syndrome of wind and dryness due to blood d

关 键 词：神应养真汤 血虚风燥型 脂溢性脱发 胰岛素样生长因子-I 肝细胞生长因子 转化生长因子-β_(2) 

分 类 号：R275.9[医药卫生—中西医结合]