具有pH响应及荧光性能的二氧化硅制备与表征  

Preparation and characterization of silica with pH response and fluorescent properties

作　　者：齐晴 李乐冰 宋雨锌 刘红瑞 张浩宇 蒲晓辉[1] 张旭[1,2] 赵彦保[2] QI Qing;LI Lebing;SONG Yuxin;LIU Hongru;ZHANG Haoyu;PU Xiaohui;ZHANG Xu;ZHAO Yanbao(College of Pharmacy,Henan Unirersity,Kaifeng 475004,Henan,China;Instiute of Nanoscience and Engineering,Henan Uniersity,Kaifeng 475004,Henan,China)

机构地区：[1]河南大学药学院,河南开封475004 [2]河南大学纳米科学与工程研究院,河南开封475004

出　　处：《化学研究》2025年第1期25-31,共7页Chemical Research

基　　金：国家自然科学基金资助项目(U1904155);河南省博士后科研启动项目(K21045Y);河南大学大学生创新创业训练计划项目(20231020002);开封市科技攻关(202202)。

摘　　要：利用十六烷基三甲基氯化铵为模板,正硅酸乙酯为硅源,3-氨丙基三乙氧基硅烷(KH550)为氨基源,通过一锅法制备出氨基化多孔二氧化硅纳米球(pSiO_(2)-NH_(2)),三乙醇胺用于调节反应体系的pH。通过pSiO_(2)表面的氨基与聚丙烯酸分子上的羧基之间发生键合作用,在pSiO_(2)表面包覆聚丙烯酸,进而形成具有pH响应特性的功能层。再将氨基化氧化锌量子点修饰在上述载体的表面,可以封堵载体孔道并赋予纳米球荧光特性。采用透射电子显微镜(TEM)、荧光激发-发射光谱(PL)、紫外-可见光吸收光谱(UV-vis)、X射线粉末衍射仪(XRD)、傅立叶变换红外光谱仪(FTIR)等对样品表面形貌、光学性质等进行分析。结果表明,pSiO_(2)表面的氨基与聚丙烯酸(PA)分子上的羧基成功键合,氨基化氧化锌量子点(ZnO-NH_(2)QDs)成功封堵,该多孔二氧化硅纳米球(pSiO_(2)/PA/ZnO)具有pH响应及荧光性能。Porous silica nanospheres(pSiO_(2)-NH_(2))were prepared by one-pot method using cetyltrimethylammo-nium chloride as template,ethyl orthosilicate as silica source,and 3-aminopropyltriethoxysilane(KH550)as amino source,and triethanolamine was used to regulate pH of reaction system,polyacrylic acid(PA)was coated on pSiO_(2)-NH_(2) surface through bonding interaction between-NH_(2) and carboxyl group,so pSiO_(2)/PA was endowed pH-responsive properties.Then,ZnO-NH_(2) QDs were modified on pSiO_(2)/PA.pSiO_(2)/PA/ZnO nanospheres were prepared with function of fluorescent properties.Morphology,structure and properties were characterized by TEM,XRD,FTIR,PL and UV-vis.The results showed that PA molecules and ZnO-NH_(2) QDs were successfully coated on pSiO_(2)-NH_(2).pSiO_(2)/PA/ZnO nanospheres have pH response and fluorescent properties.

关 键 词：PH响应 荧光性能 二氧化硅 递药系统 

分 类 号：TB383.1[一般工业技术—材料科学与工程]