2-甲基噁唑-4-羧酸的合成及晶体结构研究  

Synthesis and crystal structure of 2-methyloxazole-4-carboxylic acid

作　　者：闻硕 王浩男 赵尚勋 宋恒 徐晨 WEN Shuo;WANG Haonan;ZHAO Shangxun;SONG Heng;XU Chen(School of Entironmental and Chemical Engineering,Jiangsu University of Science and Technology,Zhenjiang212100,Jiangsu,China)

机构地区：[1]江苏科技大学环境与化学工程学院,江苏镇江212100

出　　处：《化学研究》2025年第1期40-43,共4页Chemical Research

基　　金：国家自然科学基金项目(22301110)。

摘　　要：以L-丝氨酸甲酯盐酸盐与廉价氯乙腈为原料,通过缩合闭环、消除、酯的水解三步反应,制备目标产物2-甲基噁唑-4-羧酸(3)。对反应条件进行优化,考察各种碱对中间体2-(氯甲基)-4,5-二氢噁唑-4-羧酸甲酯(1)收率的影响,控制中间体2-甲基噁唑-4-羧酸甲酯(2)反应温度,提高消除反应的效率。在优化条件下,最终目标产物(3)总收率达到76%,其详细结构进一步通过X射线单晶衍射确证。2-methyloxazole-4-carboxylic acid(3)was synthesized from L-serine methyl ester hydrochloride with chloroacetonitrile as starting materials by three steps including condensated cyclization,elimination and hydrolysis.The reaction conditions were optimized,the base factors affecting the yield of intermediate methyl 2-(chloromethyl)-1,3-oxazole-4-carboxylate(1)were investigated,and the reaction temperature of intermediate 2-methyloxazol-4-carboxylate methyl ester(2)was controlled to improve the efficiency of the elimination reaction.Under optimized conditions,the total yield of the final target product(3)reached 76%,and its detailed structure was further confirmed by X-ray single crystal diffraction.

关 键 词：2-甲基噁唑-4-羧酸 合成 工艺优化 晶体结构 

分 类 号：O626.2[理学—有机化学]