阿普米司特成功治疗难治性角层下脓疱病1例  

Refractory Subcorneal Pustular Dermatosis Successfully Treated with Apremilast:A Case Report

作　　者：周蕴奇 李佶姝 李薇[1] ZHOU Yunqi;LI Jishu;LI Wei(Department of Dermatology&Venereology,West China Hospital,Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西医院皮肤科,四川成都610041

出　　处：《中国皮肤性病学杂志》2025年第2期191-193,共3页The Chinese Journal of Dermatovenereology

基　　金：四川省自然科学基金青年科学基金项目(2024NSFSC1626)。

摘　　要：患者男,42岁,躯干反复红斑、脓疱1年余。皮肤科情况:躯干多发红斑,上覆绿豆至黄豆大小密集脓疱及少量鳞屑。躯干皮损组织病理示:表皮多灶性角层下脓疱形成。结合临床表现及组织病理考虑诊断为角层下脓疱病。患者既往曾使用“柳氮磺吡啶、异维A酸”等治疗,但症状反复,效果不佳。此次使用阿普米司特治疗2周后,躯干原有脓疱明显消退,红斑明显变暗。继续维持治疗半年,皮损未见明显复发,目前仍在进一步随访中。A 42-year-old male presented with recurrent erythema and pustules of the trunk for more than 1 year.Skin examination showed multiple erythema of the trunk,covered with dense pustules of the size of mung beans to soybeans and a small amount of scales.Histopathology of trunk skin showed multifocal subangular pustule formation.The diagnosis of subcorneal pustular dermatosis was considered in combination with clinical manifestations and skin pathology.The patient had been treated with sulfasalazine and isotretinoin in the past,but the symptoms were repeated and the effect was not good.After 2 weeks of treatment with apremilast,the skin lesions subsided significantly,and the treatment was continued for half a year,with no significant recurrence of the skin lesions.

关 键 词：阿普米司特 角层下脓疱病 

分 类 号：R758.6[医药卫生—皮肤病学与性病学]