S-(-)-尼古丁-山梨酸盐的制备、特性及其应用研究  

Study on Preparation,Characteristics and Application of S-(-)-Nicotine Sorbate

作　　者：肖智心 李江 黄晓江 何世波 刘明星 XIAO Zhixin;LI Jiang;HUANG Xiaojiang;HE Shibo;LIU Mingxing(School of Biological Engineering.and Food,Hubei Univ.of Tech.,Wuhan 430068,China;Hubei Heno Biological Engineering Co.,Ltd.,Enshi 445000,China)

机构地区：[1]湖北工业大学生物工程与食品学院,湖北武汉430068 [2]湖北和诺生物工程股份有限公司,湖北恩施445000

出　　处：《湖北工业大学学报》2025年第1期61-64,共4页Journal of Hubei University of Technology

基　　金：恩施州“揭榜制”科技计划项目(202202)。

摘　　要：为合成S-(-)-尼古丁-山梨酸盐,评估其在电子烟油中的应用潜力,提升电子烟的抽吸体验,减少S-(-)-尼古丁的氧化损失,通过超声法将S-(-)-尼古丁与山梨酸反应,成功制备S-(-)-尼古丁-山梨酸盐,并通过1H-NMR和高效液相色谱(HPLC)技术验证了其化学结构和纯度。此外,还考察了S-(-)-尼古丁-山梨酸的盐抗氧化性和热稳定性,并进行了电子烟油的评吸实验。结果显示:S-(-)-尼古丁-山梨酸盐成功合成纯度达到了99.28%,收率为95.8%。在抗氧化性测试中,S-(-)-尼古丁-山梨酸盐的有效物质损失率显著低于S-(-)-尼古丁,表现出更佳的稳定性。热稳定性分析表明,S-(-)-尼古丁-山梨酸盐的热稳定性优于S-(-)-尼古丁。评吸实验进一步证实:含有S-(-)-尼古丁-山梨酸盐的电子烟油在多个抽吸体验指标上得分高于含有S-(-)-尼古丁的电子烟油。S-(-)-尼古丁-山梨酸盐制备过程简便,其卓越的抗氧化性和热稳定性能有效改善电子烟油的抽吸体验,展现出工业化生产的潜力和市场应用前景。S-(-)-Nicotine sorbate was prepared by ultrasound using S()Nicotine and sorbic acid as raw materials with 99.28%of purity by high performance liquid chromatography,95.8%of yield and its structure was confirmed by 1 H NMR.The oxidation resistance and thermal stability of S-(-)-Nicotine sorbate were also discussed.At the same time,its application in electronic cigarette oil was evaluated through the evaluation and smoking experiment.The preparation method of S-(-)-Nicotine sorbate is simple,operable and suitable for industrial production;It effectively avoids the shortcoming of S-(-)-Nicotine perishability,and can improve the taste and pumping experience,which will have a good application prospect.

关 键 词：S-(-)-尼古丁 S-(-)-尼古丁-山梨酸盐 电子烟油 

分 类 号：O69[理学—化学]