隐孢子虫病治疗药物研究进展  

Progress on Drugs for the Treatment of Cryptosporidiosis

作　　者：马尧军 贺君君 邹丰才 马君 MA Yao-jun;HE Jun-jun;ZOU Feng-cai;MA Jun(College of Veterinary Medicine,Yunnan Agricultural University,Kunming,Yunnan,650201,China)

机构地区：[1]云南农业大学动物医学院,云南昆明650201

出　　处：《动物医学进展》2025年第2期103-108,共6页Progress In Veterinary Medicine

基　　金：云南省家畜疫病病原生物学重点实验室(202449CE340019);云南省基础研究计划农业联合专项(202201AJ070013);国家自然科学基金项目(32260889);云南省基础研究面上项目(202401AT070242)。

摘　　要：隐孢子虫是一种能够引发一系列感染性疾病的寄生原虫,这些疾病严重危害人类和动物健康,对全球的经济发展造成了重大损失。近年来在抗隐孢子虫药物领域取得了显著成效,其疗效得到了进一步研究,但目前仍没有筛选到最佳的隐孢子虫治疗药物,因此有效治疗药物的研发一直是重点。论文阐述了治疗隐孢子虫传统和新型药物种类、作用机制以及疗效试验结果,同时指出了目前存在的耐药性问题,并梳理了隐孢子虫耐药性的发生机制,提出了减少耐药性的建议,以期为治疗隐孢子虫药物的研发提供参考。Cryptosporidium is a parasitic protozoan that can cause a series of infectious diseases,which pose a serious threat to the health of humans and animals,causing significant economic losses globally.In recent years,researchers have achieved remarkable results in the field of anti-cryptosporidial drugs,with further research on their efficacy.However,the optimal drug for treating cryptosporidiosis has not yet identified,making the development of effective treatment drugs a research priority.The paper describes the types,mechanisms of action,and efficacy trial results of traditional and novel drugs for treating cryptosporidiosis.It also highlights the current issue of drug resistance and outlines the mechanisms by which resistance to anti-cryptosporidial drugs occurs.Suggestions to reduce resistance are proposed,with the aim of providing a reference for the development of drugs for treating cryptosporidiosis.

关 键 词：隐孢子虫 药物 作用机制 

分 类 号：S855.9[农业科学—临床兽医学]