癣痒解毒乳膏的制备工艺研究及药效学初探  

Preparation of Xuanyang Jiedu cream and its pharmacodynamics

作　　者：顾秦五风 张瀚文 陈婷如 孟园园 吴芸杨 杨延龙 Gu Qinwufeng;Zhang Hanwen;Chen Tingru;Meng Yuanyuan;Wu Yunyang;Yang Yanlong(Surgery of Traditional Chinese Medicine,The First Affiliated Hospital of Naval Medical University Shanghai 200433,China)

机构地区：[1]海军军医大学第一附属医院中医外科,上海200433 [2]海军第九七一医院中医科 [3]海军军医大学中医系

出　　处：《海军医学杂志》2025年第1期52-56,共5页Journal of Navy Medicine

摘　　要：目的 制备癣痒解毒乳膏,并对其进行药效学研究。方法 通过正交设计法优化癣痒解毒方中药煎煮工艺,根据乳膏的外观性状、涂展性、稳定性筛选出乳膏制备处方。取普通级健康豚鼠40只,随机分为4组(每组n=10):空白组、模型组、酮康唑乳膏组、癣痒解毒乳膏组。建立体癣豚鼠模型,探讨癣痒解毒乳膏治疗皮肤浅部真菌病的有效性。结果 优选出的流浸膏提取工艺条件为提取次数3次、加水量20倍、提取时间1.5 h,其中提取次数和加水量对流浸膏提取工艺有影响。优选出的癣痒解毒乳膏处方外观均匀细腻、黏稠,离心稳定性、耐寒及耐热稳定性均较好。对体癣豚鼠模型外用药物治疗14 d后,模型组皮损处仍有明显红斑、鳞屑、丘疹,癣痒解毒乳膏组与酮康唑乳膏组体癣豚鼠的红斑、鳞屑、丘疹皮损评分均较模型组下降(P<0.05)。结论 癣痒解毒乳膏有一定抗真菌的作用,为皮肤浅部真菌病的中西医治疗提供了新的治疗方法。Objective To prepare XuanyangJiedu cream and to study its pharmacodynamics.Methods The herbal decoction process ofXuanyangJieducream was optimized by orthogonal design method.The prescription of the cream preparation was screened according to the external properties,malleability and stability of cream.Forty normal guinea pig were randomly divided into four groups(10 in each group):blank group,model group,ketoconazole cream group,and Xuanyang Jiedu cream group.The guinea pig model of tinea corporis was established to investigate the efficacy of XuanyangJieducream in the treatment of superficial fungal disease.Results The optimal extraction conditions were 3 extractions,water added for 20 times,and 1.5 h of extraction time.The number of extractions and the amount of water significantly affected on the extraction process of the liquid extract.The optimized XuanyangJieducream looked smooth and creamy,with moderate viscosity and good stabilities of centrifuge,cold and heat resistance.After 14 d treatment,there were still obvious erythema,scales and papules on the lesions in the model group.The scores of erythema,scales and papules in the Xuanyang Jiedu cream group and the ketoconazole cream group were lower than those in the model group(P<0.05).Conclusion XuanyangJieducream has antifungal activity and may be a new treatment for skin superficial mycosis.

关 键 词：皮肤浅部真菌病 癣痒解毒方 中药 乳膏 

分 类 号：R276[医药卫生—中医五官科学]