穿膜肽非共价结合递送核酸蛋白药物研究进展  

Research process on cell penetrating peptides with non-covalent delivery of nucleic acid and protein

作　　者：陈云霞 郭琼 王雅鹃[2] 李蝉 倪蓓蓓[2] 崔京霞[1] CHEN Yunxia;GUO Qiong;WANG Yajuan;LI Chan;NI Beibei;CUI Jingxia(School of Pharmacy,Hebei Medical University,Shijiazhuang 050011,China;CSPC Zhongqi Pharmaceutical Technology(Shijiazhuang)Co.,Ltd,Shijiazhuang 050035,China)

机构地区：[1]河北医科大学药学院,河北石家庄050017 [2]石药集团中奇制药技术(石家庄)有限公司,河北石家庄050035

出　　处：《沈阳药科大学学报》2025年第2期101-107,141,共8页Journal of Shenyang Pharmaceutical University

摘　　要：细胞穿透肽可以与蛋白、核酸片段等多种生物活性分子非共价结合后将其递送到细胞中,其递送效率高,不会造成细胞损伤,进入细胞后可降解为无毒的氨基酸成分,在基因治疗、药物递送方面取得了显著的进展。穿膜肽的发现为多肽非共价结合递送系统的研究提供了新的研究方向。本文作者就近年来国内外关于穿膜肽以非共价结合方式递送核酸、蛋白药物的应用、研究方法以及影响因素等进行了综述。Cell penetrating peptides can be delivered to cells after non-covalently binding with proteins,nucleic acid fragments and other bioactive molecules,with high delivery efficiency and no cell damage.After entering cells,they can be degraded into non-toxic amino acids.Remarkable progress has been made in gene therapy and drug delivery.The discovery of transmembrane peptides provides a new research direction for the non-covalent binding delivery system of polypeptides.In this paper,the application,research methods and influencing factors of non-covalently binding delivery of nucleic acid and protein drugs by transmembrane peptides are reviewed.

关 键 词：穿膜肽 蛋白药物 核酸药物 非共价结合 纳米递送系统 

分 类 号：R94[医药卫生—药剂学]