More than the barrier effect:Biodegradable Mg-Ag alloy membranes for guided bone/tissue regeneration  

作　　者：Sihui Ouyang Xiong Wu Li Meng Xuerui Jing Liying Qiao Jia She Kai Zheng Xianhua Chen Fusheng Pan 

机构地区：[1]College of Materials Science and Engineering,Chongqing University,Chongqing 400044,China [2]National Engineering Research Center for Magnesium Alloys,Chongqing University,Chongqing 400044,China [3]National Key Laboratory of Advanced Casting Technologies,Chongqing University,Chongqing,400044,China [4]Jiangsu Key Laboratory of Oral Diseases&Jiangsu Province Engineering Research Center of Stomatological Translational Medicine,Nanjing Medical University,Nanjing 210029,China

出　　处：《Journal of Magnesium and Alloys》2024年第11期4454-4467,共14页镁合金学报(英文)

基　　金：National Natural Science Found for Distinguished Young Scholars(52225101);National Natural Science Found(52301132);China Postdoctoral Science Foundation(2022M720551);Natural Science Foundation of Chongqing(CSTB2023NSCQ-MSX0527);Chongqing Academician Special Fund(2022YSZX-JCX0014CSTB);Chongqing Science and Technology Commission(CSTB2022NSCQ-MSX0416)。

摘　　要：Magnesium(Mg)and its alloys have emerged as promising candidates for guided bone/tissue regeneration(GBR/GTR)due to their good mechanical properties,biosafety,and biodegradability.In this study,we present a pioneering application of Mg-Ag alloys featuring tunable corrosion behaviors for GBR/GTR membranes,showcasing their in vitro antibacterial effects,cell migration,and osteogenic differentiation abilities.Mg-Ag alloys with different Ag contents were engineered to facilitate the cell migration of murine fibroblasts(L929)and the osteogenic differentiation of rat bone mesenchymal stem cells(rBMSCs).The Mg-Ag alloy consisted of recrystallizedα-Mg grains and fine Mg4Ag second phases,with an observable refinement in the average grain size to 5.6μm with increasing Ag content.Among the alloys,Mg-9Ag exhibited optimal mechanical strength and moderate plasticity(tensile yield strength of 205.7 MPa,elongation of 20.3%,and a maximum bending load of 437.2 N).Furthermore,the alloying of Ag accelerated the cathodic reaction of pure Mg,leading to a slightly increased corrosion rate of the Mg-Ag alloys while maintaining acceptable general corrosion.Notably,compared with pure Mg,Mg-Ag alloys had superior antibacterial effects against Porphyromonas gingivalis(P.gingivalis)and Staphylococcus aureus(S.aureus).Taken together,these results provide evidence for the significant clinical potential of Mg-Ag alloys as GBR/GTR membranes.

关 键 词：BIODEGRADABLE Magnesium alloy ANTIBACTERIAL Guided tissue regeneration Guided bone regeneration 

分 类 号：TG146.22[一般工业技术—材料科学与工程] R783.1[金属学及工艺—金属材料]