Effect of pore geometry on properties of high-temperature oxidized additively manufactured magnesium scaffolds  

作　　者：Chaoxin Wang Shuyuan Min Jinge Liu Bingchuan Liu Bo Peng Caimei Wang Xiaolin Ma Peng Wen Yufeng Zheng Yun Tian 

机构地区：[1]Department of Orthopedics,Peking University Third Hospital,Beijing 100191,China [2]Engineering Research Center of Bone and Joint Precision Medicine,Ministry of Education,Beijing 100191,China [3]Department of Mechanical Engineering,Tsinghua University,Beijing 100084,China [4]Beijing AKEC Medical Co.,Ltd.,Beijing 102200,China [5]School of Materials Science and Engineering,Peking University,Beijing 100871,China

出　　处：《Journal of Magnesium and Alloys》2024年第11期4509-4520,共12页镁合金学报(英文)

基　　金：National Key Research and Development Program of China (2018YFE0104200);Youth Innovation Promotion Association CAS (2019031);National Natural Science Foundation of China (51875310,52175274, 82172065)。

摘　　要：Only a few studies have examined how pore geometry affects the mechanical characteristics, biological behavior, and degradation of additively manufactured biodegradable porous magnesium. In this work, the effects of pore geometry on mechanical qualities, degradation,and biological behavior were investigated using three typical porous architectures with the same porosity. The porous structures were found to satisfy bone tissue engineering requirements because they had sufficient degradation resistance and tunable compressive characteristics. All three types of magnesium alloy scaffolds exhibited good biocompatibility. Additionally, the magnesium alloy porous structures influenced the magnesium scaffold material degradation rate and the surrounding environment, impacting the osteogenic differentiation of bone mesenchymal stem cells and bone tissue regeneration. This work offers conceptual support for optimizing pore geometry to alter the mechanical and degradable characteristics of additively manufactured porous magnesium to meet therapeutic demands.

关 键 词：Pore geometry Additive manufacturing WE43 alloy Magnesium alloy 

分 类 号：R318.08[医药卫生—生物医学工程] TG146.22[医药卫生—基础医学]