LISA技术联合经鼻双水平无创正压通气治疗早产儿呼吸窘迫综合征的优势分析  

Analysis of the advantages of LISA combined with nasal Duo positive airway pressure ventilation in the treatment of respiratory distress syndrome in premature infants

作　　者：仝实 龚莉 朱尚品 段晓艳 韩梅 武凡玙 柴凤云 TONG Shi;GONG Li;ZHU Shang-pin(Suining Branch Hospital of Xuzhou Medical University Affiliated Hospital,Suining County People's Hospital,Xuzhou 221200,China)

机构地区：[1]徐州医科大学附属医院睢宁分院,睢宁县人民医院,221200

出　　处：《中国实用医药》2025年第2期16-19,共4页China Practical Medicine

基　　金：江苏省卫生健康委科研项目(项目编号:Z2020060)。

摘　　要：目的探讨微创表面活性物质运用技术(LISA技术)联合经鼻双水平无创正压通气治疗早产儿呼吸窘迫综合征的效果。方法以呼吸窘迫综合征早产儿72例作为研究目标,采用随机数字表法分为对照组和观察组,每组36例。对照组早产儿以经鼻持续气道正压通气(NCPAP)治疗,观察组早产儿以LISA技术联合经鼻双水平无创正压通气治疗。比较两组早产儿治疗后血气指标及并发症发生情况。结果治疗后1、6 h,观察组早产儿氧合指数(OI)(182.63±6.59)、(197.93±7.18)mm Hg(1 mm Hg=0.133 kPa)和动脉血氧分压(PaO_(2))(63.79±3.92)、(72.11±2.88)mm Hg高于对照组的(160.33±6.62)、(185.24±7.06)mm Hg和(60.22±3.95)、(69.06±2.85)mm Hg,动脉血二氧化碳分压(PaCO_(2))(40.25±2.11)、(37.11±1.03)mm Hg低于对照组的(43.62±2.14)、(39.02±1.05)mm Hg(P<0.05)。观察组早产儿治疗后并发症发生率2.78%低于对照组的25.00%(P<0.05)。结论呼吸窘迫综合征早产儿经过LISA技术联合经鼻双水平无创正压通气治疗效果确切,可有效改善患儿血气指标,减少并发症,值得推广。Objective To explore the effect of less invasive surfactant administration(LISA)combined with noninvasive bilevel positive pressure ventilation in the treatment of respiratory distress syndrome in premature infants.Methods 60 premature infants with respiratory distress syndrome were selected as study subjects and divided into a control group and an observation group using a random number table method,each consisting of 36 cases.The control group was treated with nasal continuous positive airway pressure ventilation(NCPAP),and the observation group was treated with LISA combined with noninvasive bilevel positive pressure ventilation.The blood gas indicators and complications after treatment were compared between the two groups.Results After 1 and 6 h of treatment,the oxygenation index(OI)of preterm infants in the observation group were(182.63±6.59)and(197.93±7.18)mm Hg(1 mm Hg=0.133 kPa),and the arterial partial pressure of oxygen(PaO_(2))were(63.79±3.92)and(72.11±2.88)mm Hg,which were higher than(160.33±6.62),(185.24±7.06)mm Hg and(60.22±3.95),(69.06±2.85)mm Hg in the control group;the arterial partial blood pressure of carbon dioxide(PaCO_(2))were(40.25±2.11)and(37.11±1.03)mm Hg in the observation group,which were lower than(43.62±2.14)and(39.02±1.05)mm Hg in the control group(P<0.05).The complication rate of 2.78% in the observation group was lower than 25.00% in the control group(P<0.05).Conclusion The combination of LISA and nasal DuoPAP is effective in treating premature infants with respiratory distress syndrome,and can effectively improve their blood gas indicators and reduce complications.It is worth promoting.

关 键 词：微创表面活性物质运用技术 经鼻双水平无创正压通气 早产儿 呼吸窘迫综合征 经鼻持续气道正压通气 

分 类 号：R72[医药卫生—儿科]