帕拉米韦氯化钠注射液治疗小儿流感的临床疗效  

Clinical efficacy of peramivir and sodium chloride injection on infantile influenza

作　　者：王晶晶 刘思祺 吴玉秀 孟文芳 WANG Jing-jing;LIU Si-qi;WU Yu-xiu(Department of Pediatrics,Xuzhou Mining Group General Hospital,Xuzhou 221006,China)

机构地区：[1]徐州矿务集团总医院儿科,221006

出　　处：《中国实用医药》2025年第2期34-37,共4页China Practical Medicine

摘　　要：目的研究小儿流行性感冒(流感)给予帕拉米韦氯化钠注射液治疗的临床效果。方法选取72例流感患儿,按照随机数字表法分成对照组和观察组,各36例。对照组采用磷酸奥司他韦治疗,观察组采用帕拉米韦氯化钠注射液治疗。比较两组临床疗效,症状缓解时间,肝肾功能和不良反应发生情况。结果观察组总有效率94.44%高于对照组的75.00%,差异显著(P<0.05);观察组咳嗽咳痰缓解时间(2.86±0.78)d、退热时间(1.49±0.64)d、扁桃体红肿缓解时间(4.20±1.28)d、鼻塞流涕缓解时间(4.17±1.08)d均短于对照组的(4.29±0.94)、(3.08±1.17)、(5.28±1.35)、(5.14±1.15)d,差异显著(P<0.05);两组治疗前后肝肾功能指标组间比较无显著差异(P>0.05);观察组不良反应发生率为5.56%,低于对照组的27.78%,差异显著(P<0.05)。结论帕拉米韦氯化钠注射液治疗小儿流感的临床疗效显著,可缩短症状缓解时间,降低不良反应发生率,利于病症好转,值得推广。Objective To study the clinical effect of peramivir and sodium chloride injection on infantile influenza.Methods A total of 72 cases of infantile influenza were selected,and divided into a control group and an observation group by random number table method,with 36 cases in each group.The control group was treated with oseltamivir phosphate,and the observation group was treated with peramivir and sodium chloride injection.The clinical efficacy,the duration of symptom remission,liver and kidney function and adverse reactions were compared between the two groups.Results The total effective rate of 94.44% in the observation group was higher than 75.00% in the control group,and the difference was significant(P<0.05).In the observation group,the remission time of cough and sputum was(2.86±0.78)d,the fever reduction time was(1.49±0.64)d,the remission time of tonsil redness and swelling was(4.20±1.28)d,and the remission time of nasal obstruction and runny nose was(4.17±1.08)d,which were shorter than(4.29±0.94),(3.08±1.17),(5.28±1.35),and(5.14±1.15)d in the control group,and the difference was significant(P<0.05).There were no significant differences in liver and kidney function indexes between the two groups before and after treatment(P>0.05).The incidence of adverse reactions in the observation group was 5.56%,which was significantly lower than 27.78% in the control group(P<0.05).Conclusion The clinical effect of peramivir and sodium chloride treatment in children with influenza is significant,which can shorten the duration of symptom remission,reduce the incidence of adverse reactions,and is conducive to the improvement of the disease.It is worthy of promotion.

关 键 词：帕拉米韦氯化钠注射液 奥司他韦 小儿流行性感冒 症状缓解时间 肝肾功能指标 不良反应 

分 类 号：R72[医药卫生—儿科]