缬沙坦氨氯地平片(Ⅰ)治疗老年高血压的临床效果分析  

Clinical effect analysis of valsartan and amlodipine tablets(Ⅰ)in the treatment of senile hypertension

作　　者：徐云晓 XU Yun-xiao(Department of Pharmacy,Jinan Tianqiao People's Hospital,Jinan 250031,China)

机构地区：[1]济南市天桥人民医院药剂科,250031

出　　处：《中国实用医药》2025年第2期98-101,共4页China Practical Medicine

摘　　要：目的探析老年高血压患者行缬沙坦氨氯地平片(Ⅰ)治疗的临床效果。方法80例老年高血压患者,根据硬币法分为对照组和观察组,每组40例。对照组行缬沙坦胶囊治疗,观察组行缬沙坦氨氯地平片(Ⅰ)治疗。对比两组患者的疗效及治疗前后血压指标(收缩压、舒张压、收缩压昼夜节律、舒张压昼夜节律)、血液流变学指标(全血高切粘度、血浆粘度、纤维蛋白原)。结果观察组患者治疗总有效率为97.50%,高于对照组的85.00%,存在统计学意义(P<0.05)。治疗后,两组患者的收缩压、舒张压低于本组治疗前,收缩压昼夜节律、舒张压昼夜节律高于本组治疗前,且观察组患者的收缩压(120.65±6.98)mm Hg(1 mm Hg=0.133 kPa)、舒张压(77.98±6.58)mm Hg低于对照组的(126.69±6.85)、(80.96±6.57)mm Hg,收缩压昼夜节律(7.11±0.35)%、舒张压昼夜节律(4.89±0.23)%高于对照组的(6.61±0.30)%、(4.12±0.33)%,存在统计学意义(P<0.05)。治疗后,两组患者的全血高切粘度、血浆粘度、纤维蛋白原均低于本组治疗前,且观察组患者的全血高切粘度(4.43±0.28)mPa·s、血浆粘度(1.21±0.26)mPa·s、纤维蛋白原(3.82±0.45)g/L均低于对照组的(4.90±0.29)mPa·s、(1.80±0.33)mPa·s、(4.36±0.31)g/L,存在统计学意义(P<0.05)。结论老年高血压患者采用缬沙坦氨氯地平片(Ⅰ)治疗的疗效显著,可以推广。Objective To explore the clinical effect of valsartan and amlodipine tablets(Ⅰ)in the treatment of senile hypertension.Methods 80 senile patients with hypertension were divided into control group and observation group according to coin-tossing method,with 40 cases in each group.The control group was treated with valsartan capsule,and the observation group was treated with valsartan and amlodipine tablets(Ⅰ).Comparison was made on efficacy,blood pressure indexes(systolic and diastolic blood pressure,circadian rhythm of diastolic and diastolic blood pressure)and hemorheology indexes(whole-blood high-shear viscosity,plasma viscosity,fibrinogen)before and after treatment between the two groups.Results The total effective rate of 97.50% in the observation group was higher than 85.00% in the control group,and there was statistical significance(P<0.05).After treatment,the systolic and diastolic blood pressure in both groups were lower than those before treatment,and the circadian rhythm of diastolic and diastolic blood pressure were higher than those before treatment;the systolic and diastolic blood pressure were(120.65±6.98)and(77.98±6.58)mm Hg(1 mm Hg=0.133 kPa)in the observation group,which were lower than(126.69±6.85)and(80.96±6.57)mm Hg in the control group;the circadian rhythm of diastolic and diastolic blood pressure were(7.11±0.35)% and(4.89±0.23)% in the observation group,which were higher than(6.61±0.30)% and(4.12±0.33)% in the control group;there was statistical significance(P<0.05).After treatment,the whole-blood high-shear viscosity,plasma viscosity and fibrinogen in both groups were lower than those before treatment;in the observation group,the whole-blood high-shear viscosity was(4.43±0.28)mPa·s,the plasma viscosity was(1.21±0.26)mPa·s and the fibrinogen was(3.82±0.45)g/L,which were lower than(4.90±0.29)mPa·s,(1.80±0.33)mPa·s and(4.36±0.31)g/L in the control group;there was statistical significance(P<0.05).Conclusion The efficacy of valsartan and amlodipine tablets(Ⅰ)in the treatme

关 键 词：老年高血压 缬沙坦氨氯地平片 疗效 血液流变学 

分 类 号：R54[医药卫生—心血管疾病]