维生素D滴剂联合抗生素治疗社区获得性肺炎患儿的临床效果分析  

Clinical effect analysis of vitamin D drops combined with antibiotics in the treatment of children with community-acquired pneumonia

作　　者：秦立莉 马国栋 QIN Li-li;MA Guo-dong(Department of Pediatrics,Weishan County People's Hospital,Jining 277600,China)

机构地区：[1]微山县人民医院儿科,277600 [2]微山县人民医院骨科,277600

出　　处：《中国实用医药》2025年第2期106-109,共4页China Practical Medicine

摘　　要：目的研究维生素D滴剂联合抗生素治疗社区获得性肺炎患儿的临床效果。方法300例社区获得性肺炎患儿,通过随机数字表法分为对照组与观察组,每组150例。对照组在常规治疗的基础上实施抗生素治疗,观察组则在对照组基础上加用维生素D滴剂治疗。对比两组的血清学指标[白细胞计数(WBC)、中性粒细胞比例(NEUT%)、红细胞沉降率(ESR)、C反应蛋白(CRP)、降钙素原(PCT)、白细胞介素-6(IL-6)],血气分析指标[动脉血氧分压(PaO_(2))、血氧饱和度(SaO_(2))、动脉血二氧化碳分压(PaCO_(2))],血清钙离子(Ca^(2+))、25-羟维生素D水平,临床症状消失时间,不良反应发生情况,临床疗效。结果治疗后,两组患儿的WBC、NEUT%、ESR、CRP、PCT、IL-6均较入组时降低,且观察组患儿的WBC(7.30±0.75)×10^(9)/L、NEUT%(50.71±2.05)%、ESR(28.20±1.11)mm/h、CRP(7.50±0.80)mg/L、PCT(0.34±0.05)μg/L、IL-6(7.83±1.30)ng/L均低于对照组的(10.11±1.09)×10^(9)/L、(65.23±3.10)%、(32.09±1.71)mm/h、(10.23±1.16)mg/L、(0.78±0.14)μg/L、(12.31±1.69)ng/L(P<0.05)。治疗后,两组患儿的血清Ca^(2+)、25-羟维生素D水平均高于入组时,且观察组患儿的血清Ca^(2+)(2.56±0.28)mmol/L、25-羟维生素D(66.49±6.32)nmol/L高于对照组的(2.09±0.23)mmol/L、(58.25±5.17)nmol/L(P<0.05)。治疗后,两组患儿的PaO_(2)、SaO_(2)、PaCO_(2)均较入组时改善,且观察组患儿的PaO_(2)(86.20±5.37)mm Hg(1 mm Hg=0.133 kPa)、SaO_(2)(93.67±4.55)%高于对照组的(80.54±4.16)mm Hg、(89.19±3.49)%,PaCO_(2)(37.90±1.64)mm Hg低于对照组的(42.75±2.01)mm Hg(P<0.05)。与对照组对比,观察组患儿的退热时间、咳嗽消失时间、气促消失时间、肺部啰音消失时间均更短(P<0.05)。两组不良反应发生率对比差异不大(P>0.05)。与对照组对比,观察组的临床总有效率更高(P<0.05)。结论在社区获得性肺炎患儿的治疗中应用维生素D滴剂联合抗生素用药方案安全有效,可有效减轻�Objective To study the clinical effect of vitamin D drops combined with antibiotics in the treatment of children with community-acquired pneumonia.Methods 300 children with communityacquired pneumonia were divided into control group and observation group by random number table method,with 150 cases in each group.The control group was treated with antibiotics on the basis of conventional treatment,and the observation group was treated with vitamin D drops on the basis of the control group.Both groups were compared in terms of serological parameters[white blood cell count(WBC),neutrophil percentage(NEUT%),erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),procalcitonin(PCT),interleukin-6(IL-6)],blood gas analysis indicators[arterial partial pressure of oxygen(PaO_(2)),oxygen saturation(SaO_(2)),arterial partial pressure of carbon dioxide(PaCO_(2))],serum calcium ion(Ca^(2+)),25-hydroxyvitamin D level,duration of clinical symptoms,occurrence of adverse reactions,and clinical efficacy.Results After treatment,WBC,NEUT%,ESR,CRP,PCT and IL-6 in both groups were decreased compared with those at the time of enrollment;the observation group had WBC of(7.30±0.75)×10^(9)/L,NEUT% of(50.71±2.05)%,ESR of(28.20±1.11)mm/h,CRP of(7.50±0.80)mg/L,PCT of(0.34±0.05)μg/L,and IL-6 of(7.83±1.30)ng/L,which were lower than(10.11±1.09)×10^(9)/L,(65.23±3.10)%,(32.09±1.71)mm/h,(10.23±1.16)mg/L,(0.78±0.14)μg/L,and(12.31±1.69)ng/L in the control group(P<0.05).After treatment,the levels of serum Ca^(2+)and 25-hydroxyvitamin D in both groups were higher than those at the time of enrollment;the serum Ca^(2+)and 25-hydroxyvitamin D were(2.56±0.28)mmol/L and(66.49±6.32)nmol/L in the observation group,which were higher than(2.09±0.23)mmol/L and(58.25±5.17)nmol/L in the control group(P<0.05).After treatment,PaO_(2),SaO_(2)and PaCO_(2)in both groups were improved compared with those at the time of enrollment;the observation group had PaO_(2)of(86.20±5.37)mm Hg(1 mm Hg=0.133 kPa)and SaO_(2)of(93.67±4.55)%,which were higher

关 键 词：社区获得性肺炎 维生素D滴剂 抗生素 儿童 

分 类 号：R72[医药卫生—儿科]