探讨静脉滴注人免疫球蛋白联合糖皮质激素冲击疗法治疗小儿支原体肺炎的有效性及安全性  

The effectiveness and safety of intravenous infusion of human immunoglobulin combined with glucocorticoid pulse therapy in the treatment of mycoplasma pneumonia in children

作　　者：孟康 MENG Kang(Tai'an Maternal and Child Health Hospital,Tai'an 271000,China)

机构地区：[1]泰安市妇幼保健院,271000

出　　处：《中国实用医药》2025年第2期110-113,共4页China Practical Medicine

摘　　要：目的观察对小儿支原体肺炎患儿给予静脉滴注人免疫球蛋白联合糖皮质激素冲击疗法治疗的有效性及安全性。方法选择147例小儿支原体肺炎患儿,以电脑随机形式分成对照组(73例)和观察组(74例)。对照组采取常规治疗及静脉滴注人免疫球蛋白治疗,观察组在对照组基础上加以糖皮质激素冲击疗法治疗。比较两组治疗效果、不良反应发生率及治疗前后血清炎性因子、免疫球蛋白、肺功能。结果与同组治疗前比较,两组治疗后白细胞介素-6、白细胞介素-8、C反应蛋白水平显著降低(P<0.05);与对照组的(61.86±15.13)pg/ml、(16.05±1.73)ng/ml、(17.65±2.32)mg/L比较,观察组治疗后白细胞介素-6(52.40±17.21)pg/ml、白细胞介素-8(11.22±1.07)ng/ml、C反应蛋白(9.50±1.83)mg/L显著更低(P<0.05)。与同组治疗前比较,两组治疗后免疫球蛋白A、免疫球蛋白G、免疫球蛋白M水平显著升高(P<0.05);观察组治疗后免疫球蛋白A、免疫球蛋白G、免疫球蛋白M水平与对照组比较未见明显差异性(P>0.05)。与同组治疗前比较,两组治疗后用力呼气量、最大呼气流速、最大呼气中段流量显著升高(P<0.05);与对照组比较,观察组治疗后用力呼气量、最大呼气流速、最大呼气中段流量显著更高(P<0.05)。与对照组(79.45%)比较,观察组治疗总有效率(91.89%)显著更高(P<0.05)。观察组不良反应发生率与对照组比较未见明显差异性(P>0.05)。结论静脉滴注人免疫球蛋白联合糖皮质激素冲击疗法可提高小儿支原体肺炎的临床效果,减轻机体炎症反应,改善患儿免疫功能及肺功能,且安全性较高。Objective To observe the effectiveness and safety of intravenous infusion of human immunoglobulin combined with glucocorticoid pulse therapy in the treatment of mycoplasma pneumonia in children.Methods A total of 147 children with mycoplasma pneumonia were randomly divided into control group(73 cases)and observation group(74 cases).The control group received conventional treatment and intravenous infusion of human immunoglobulin treatment,and the observation group was treated with glucocorticoid pulse therapy on the basis of the control group.The therapeutic effect,incidence of adverse reactions,serum inflammatory factors,immunoglobulin and lung function before and after treatment were compared between the two groups.Results Compared with before treatment,the levels of interleukin-6,interleukin-8 and C-reactive protein in both groups after treatment were significantly lower(P<0.05).Compared with(61.86±15.13)pg/ml,(16.05±1.73)ng/ml and(17.65±2.32)mg/L in the control group,the levels of interleukin-6(52.40±17.21)pg/ml,interleukin-8(11.22±1.07)ng/ml and C-reactive protein(9.50±1.83)mg/L were significantly decreased in the observation group after treatment(P<0.05).Compared with before treatment,the levels of immunoglobulin A,immunoglobulin G and immunoglobulin M in both groups were significantly increased after treatment(P<0.05).There were no significant differences in the levels of immunoglobulin A,immunoglobulin G and immunoglobulin M between the observation group and the control group after treatment(P>0.05).Compared with before treatment,the forced expiratory volume,maximum expiratory flow rate and maximum mid-expiratory flow in both groups were significantly increased after treatment(P<0.05).Compared with the control group,the forced expiratory volume,maximum expiratory flow rate and maximum mid-expiratory flow were significantly increased after treatment in the observation group(P<0.05).Compared with the control group(79.45%),the total effective rate of the observation group(91.89%)was significantly highe

关 键 词：静脉滴注 人免疫球蛋白 糖皮质激素冲击疗法 小儿支原体肺炎 

分 类 号：R72[医药卫生—儿科]