盐酸坦洛新缓释胶囊治疗输尿管结石的临床疗效观察  

Observation on clinical efficacy of tamsulosin hydrochloride sustained-release capsules in the treatment of ureteral stones

作　　者：孙守刚 刘冉 SUN Shou-gang;LIU Ran(Department of Urology,Taierzhuang District People's Hospital,Zaozhuang 277400,China)

机构地区：[1]台儿庄区人民医院泌尿外科,277400

出　　处：《中国实用医药》2025年第2期128-131,共4页China Practical Medicine

摘　　要：目的评价盐酸坦洛新缓释胶囊治疗输尿管结石的临床疗效。方法选取输尿管结石患者86例为研究对象,应用奇偶分组法将患者分为参照组和试验组,每组43例。参照组给予五淋化石胶囊治疗,试验组在参照组治疗基础上结合盐酸坦洛新缓释胶囊治疗。比较两组临床疗效、结石排出情况、生活质量、不良反应发生情况。结果试验组临床总有效率95.35%高于参照组的79.07%,有统计价值(P<0.05)。试验组治疗3 d、1周、2周、4周后的结石排出率分别为46.51%、58.14%、72.09%、93.02%,高于参照组的25.58%、34.88%、51.16%、74.42%,有统计价值(P<0.05)。治疗后,试验组生理功能、社会功能、躯体疼痛、生理职能、精神健康评分分别为(67.12±5.63)、(69.05±6.37)、(68.84±5.23)、(65.49±5.21)、(70.14±4.82)分,均高于参照组的(61.83±4.96)、(60.11±5.51)、(62.45±5.04)、(57.41±4.53)、(63.69±4.71)分,有统计价值(P<0.05)。两组不良反应发生率比较无明显差异(P>0.05)。结论盐酸坦洛新缓释胶囊治疗输尿管结石的效果优势明显,能够提高结石排除率,且不会增加患者的不良反应,可促使患者的生活质量提升,值得应用于临床。Objective To evaluate the clinical efficacy of tamsulosin hydrochloride sustained-release capsules in the treatment of ureteral stones.Methods A total of 86 patients with ureteral stones were selected,and they were divided into reference group and experimental group using odd-even grouping method,each consisting of 43 cases.The reference group was treated with Wulin Huashi capsule,while the experimental group was treated with tamsulosin hydrochloride sustained-release capsules based on the reference group.The clinical efficacy,stone removal,quality of life,and occurrence of adverse reactions were compared between the two groups.Results The total clinical effective rate of 95.35% in the experimental group was higher than 79.07% in the reference group,and had statistical value(P<0.05).After 3 d,1 week,2 weeks and 4 weeks of treatment,the stone removal rates in the experimental group were 46.51%,58.14%,72.09% and 93.02%,which were higher than 25.58%,34.88%,51.16% and 74.42% in the reference group,and had statistical value(P<0.05).After treatment,the scores of physical function,social function,bodily pain,role-physical and mental health of the experimental group were(67.12±5.63),(69.05±6.37),(68.84±5.23),(65.49±5.21)and(70.14±4.82)points,which were higher than(61.83±4.96),(60.11±5.51),(62.45±5.04),(57.41±4.53)and(63.69±4.71)points in the reference group,and had statistical value(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The application of tamsulosin hydrochloride sustained-release capsules has obvious advantages in the treatment of ureteral stones,which can improve the stone removal rate without increasing the adverse reactions of patients,and can promote the improvement of quality of life of patients.It is worthy of clinical application.

关 键 词：输尿管结石 药物治疗 盐酸坦洛新缓释胶囊 

分 类 号：R69[医药卫生—泌尿科学]