布托啡诺复合多拉司琼预防剖宫产术中卡前列素氨丁三醇不良反应的效果观察  

Effect observation of butorphanol combined with dolasetron in preventing adverse reactions of carboprost tromethamine in cesarean section

作　　者：孙豹 王笑 解晓庆 SUN Bao;WANG Xiao;XIE Xiao-qing(Department of Anesthesia,Shunyi District Hospital,Beijing 101300,China)

机构地区：[1]北京市顺义区医院麻醉科,101300

出　　处：《中国实用医药》2025年第2期143-145,共3页China Practical Medicine

摘　　要：目的讨论布托啡诺复合多拉司琼在剖宫产术中预防卡前列素氨丁三醇不良反应的效果。方法选择行择期剖宫产术的足月产妇90例,采用随机数字表法将产妇分为CP组、P组和N组,每组30例。所有产妇椎管内麻醉用药方案一致。CP组采用布托啡诺联合多拉司琼静脉注射治疗,P组采用多拉司琼静脉注射治疗,N组采用生理盐水静脉注射治疗。比较三组不同时间Ramsay镇静评分及不良反应发生情况。结果入室时(T0)时,三组Ramsay镇静评分比较,差异均无统计学意义(P>0.05)。注射卡前列素氨丁三醇后10 min(T1)、术毕(T2)时,CP组Ramsay镇静评分高于N组、P组,T1时P组Ramsay镇静评分高于N组,差异有统计学意义(P<0.05)。与T0时比较,N组、P组T1时Ramsay镇静评分均降低,且N组降低显著,CP组T1、T2时Ramsay镇静评分均升高,差异有统计学意义(P<0.05)。与T1时比较,N组T2时Ramsay镇静评分升高,差异有统计学意义(P<0.05)。CP组面色潮红、胸闷、恶心、呕吐发生率分别为6.7%、3.3%、6.7%、0,P组分别为36.7%、30.0%、36.7%、23.3%,N组分别为43.3%、40.0%、73.3%、60.0%。CP组恶心、呕吐、胸闷、面色潮红的发生率明显低于N组及P组,P组恶心、呕吐的发生率明显低于N组,差异有统计学意义(P<0.05)。结论布托啡诺与多拉司琼联合应用可以有效减少剖宫产术中因应用卡前列素氨丁三醇导致的不良反应,缓解产妇不适感,具有一定的镇静效果,优于单独使用多拉司琼,从而降低不良反应的发生率。Objective To discuss the effect of butorphanol combined with dolasetron in preventing adverse reactions of carboprost tromethamine in cesarean section.Methods A total of 90 full-term pregnant women who underwent cesarean section were selected,and divided into CP group,P group and N group according to random numerical table,with 30 cases in each group.The intraspinal anesthesia medication regimen was the same in all patients.CP group was given intravenous injection of butorphanol+dolasetron,P group was given intravenous injection of dolasetron,and N group was given intravenous injection of normal saline.The Ramsay sedation scores at different time points and occurrence of adverse reactions of the three groups were compared.Results At the time of entry(T0),there was no statistically significant difference in Ramsay sedation score among the three groups(P>0.05).10 min after injection of carboprost tromethamine(T1)and after operation(T2),the Ramsay sedation score in CP group was higher than that in N group and P group;at T1,the Ramsay sedation score in P group was higher than that in N group;the difference was statistically significant(P<0.05).Compared with that at T1,the Ramsay sedation score of N group increased at T2,and the difference was statistically significant(P<0.05).The incidence of adverse reactions of facial flushing,chest tightness,nausea and vomiting were 6.7%,3.3%,6.7% and 0 in CP group,36.7%,30.0%,36.7% and 23.3% in P group,and 43.3%,40.0%,73.3% and 60.0%in N group.The incidence of nausea,vomiting,chest tightness and facial flushing in CP group was significantly lower than that in N group and P group,and the incidence of nausea and vomiting in P group was significantly lower than that in N group.The difference was statistically significant(P<0.05).Conclusion Butorphanol combined with dolasetron has better effects than the use of dolasetron alone,which can effectively reduce the adverse reactions caused by the use of carboprost tromethamine in cesarean section,alleviate maternal discomfort,and have a c

关 键 词：布托啡诺 多拉司琼 卡前列素氨丁三醇 剖宫产 不良反应 

分 类 号：R47[医药卫生—护理学]