马来酸麦角新碱联合卡前列素氨丁三醇预防剖宫产产后出血的效果观察  

Observation on the effect of ergometrine maleate combined with carboprost tromethamine in preventing postpartum hemorrhage after cesarean section

作　　者：丘东梅 黄林秀 苏春梅[1] QIU Dong-mei;HUANG Lin-xiu;SU Chun-mei(Suixi County People's Hospital,Zhanjiang 524300,China)

机构地区：[1]遂溪县人民医院,524300

出　　处：《中国实用医药》2025年第2期146-149,共4页China Practical Medicine

基　　金：观察马来酸麦角新碱联合卡前列素氨丁三醇治疗剖宫产产后出血的控制效果(项目编号:2022B01082)。

摘　　要：目的探讨马来酸麦角新碱联合卡前列素氨丁三醇预防剖宫产产后出血的效果。方法88例高危剖宫产产妇,运用单双数字抽签法分成实践组(n=44)与普通组(n=44)。实践组采取马来酸麦角新碱联合卡前列素氨丁三醇治疗,普通组采取卡前列素氨丁三醇治疗。比较两组凝血功能[血浆纤维蛋白原(Fib)、凝血酶原时间(PT)、凝血酶时间(TT)、活化部分凝血活酶时间(APTT)]、血常规指标[红细胞(RBC)、红细胞压积(HCT)、血红蛋白(Hb)]、生产后出血量、不良反应发生率。结果治疗后,实践组Fib(3.95±0.75)g/L高于普通组的(3.42±0.77)g/L,PT(13.25±0.57)s、TT(14.49±3.51)s、APTT(22.14±1.65)s短于普通组的(14.87±0.65)、(15.45±3.33)、(23.24±1.75)s,统计学差异明显(P<0.05)。治疗后,实践组RBC(4.89±1.11)×10^(12)/L、HCT(36.78±4.25)%、Hb(130.74±10.36)g/L均高于普通组的(3.46±1.04)×10^(12)/L、(32.21±3.37)%、(123.05±9.69)g/L,统计学差异明显(P<0.05)。实践组生产后60 min、61~120 min、121~240 min、241 min~1 d的出血量均少于普通组,统计学差异明显(P<0.05)。实践组不良反应发生率4.55%低于普通组的18.18%,统计学差异明显(P<0.05)。结论马来酸麦角新碱联合卡前列素氨丁三醇预防剖宫产产后出血的疗效显著,止血效果较为理想,该方案具有一定推广价值。Objective To explore the effect of ergometrine maleate combined with carboprost tromethamine in preventing postpartum hemorrhage after cesarean section.Methods 88 high-risk pregnant women with cesarean section were divided into practice group(n=44)and general group(n=44)by oddeven number lottery method.The practice group was treated with ergotrine maleate combined with carboprost tromethamine,and the general group was treated with carboprost tromethamine.Comparison was made on coagulation function[plasma fibrinogen(Fib),prothrombin time(PT),thrombin time(TT),activated partial thromboplastin time(APTT)],blood routine indexes[red blood cell count(RBC),hematocrit(HCT),hemoglobin(Hb)],postpartum blood loss and incidence of adverse reactions between the two groups.Results After treatment,Fib of(3.95±0.75)g/L in the practice group was higher than(3.42±0.77)g/L in the general group;the practice group had PT of(13.25±0.57)s,TT of(14.49±3.51)s,and APTT of(22.14±1.65)s,which were shorter than(14.87±0.65),(15.45±3.33),and(23.24±1.75)s in the general group;the differences were statistically significant(P<0.05).After treatment,the practice group had RBC of(4.89±1.11)×10^(12)/L,HCT of(36.78±4.25)% and Hb of(130.74±10.36)g/L,which were higher than(3.46±1.04)×10^(12)/L,(32.21±3.37)% and(123.05±9.69)g/L in the general group,and the differences were statistically significant(P<0.05).The blood loss at 60 min,61-120 min,121-240 min and 241 min-1 d after delivery in the practice group was lower than those in the general group,and the differences were statistically significant(P<0.05).The incidence of adverse reactions of 4.55% in the practice group was lower than 18.18% in the general group,and the difference was statistically significant(P<0.05).Conclusion The curative effect of ergometrine maleate combined with carboprost tromethamine in preventing postpartum hemorrhage after cesarean section is remarkable,and the hemostatic effect is ideal.This regimen contains a certain value of popularization.

关 键 词：马来酸麦角新碱 卡前列素氨丁三醇 剖宫产 产后出血 

分 类 号：R71[医药卫生—妇产科学]