坤泰胶囊配合激素替代治疗对卵巢早衰患者卵巢功能及血清内分泌激素的影响分析  

Analysis of the effects of Kuntai capsule combined with hormone replacement therapy on ovarian function and serum endocrine hormones in patients with premature ovarian failure

作　　者：赵殿红[1] ZHAO Dian-hong(Lixia District Third People's Hospital,Jinan 250000,China)

机构地区：[1]济南市历下区第三人民医院,250000

出　　处：《中国实用医药》2025年第2期167-170,共4页China Practical Medicine

摘　　要：目的观察卵巢早衰患者应用坤泰胶囊配合激素替代治疗的效果,为临床提供借鉴。方法随机选择卵巢早衰患者70例,以入院顺序将其分成对照组(35例)与观察组(35例)。对照组给予激素替代治疗,观察组给予坤泰胶囊配合激素替代治疗。比较两组治疗前后的临床症状积分、卵巢功能、卵巢血流参数、血清内分泌激素、生活质量评分。结果两组治疗后头晕耳鸣、腰膝酸软、月经异常积分较本组治疗前显著下降,且观察组治疗后头晕耳鸣积分(1.42±0.16)分、腰膝酸软积分(1.39±0.14)分、月经异常积分(1.24±0.17)分低于对照组的(2.15±0.21)、(2.63±0.20)、(2.10±0.11)分(P<0.05)。两组治疗后窦卵泡数、卵巢体积、卵巢直径较本组治疗前显著增加,且观察组治疗后窦卵泡数(5.80±0.21)个、卵巢体积(6.65±0.51)cm^(3)、卵巢直径(20.23±2.12)mm大于对照组的(3.71±0.30)个、(5.79±0.60)cm^(3)、(17.93±2.49)mm(P<0.05)。两组治疗后双侧卵巢血流流速较本组治疗前显著上升,阻力指数、搏动指数较本组治疗前显著下降,且观察组治疗后双侧卵巢血流流速(12.61±3.86)cm/s大于对照组的(9.97±3.58)cm/s、阻力指数(0.59±0.10)和搏动指数(0.63±0.12)低于对照组的(0.83±0.19)和(0.81±0.15)(P<0.05)。治疗后,两组血清雌二醇、卵泡刺激素、促黄体生成素较本组治疗前明显改善,且观察组血清雌二醇(95.81±3.36)pg/ml高于对照组的(89.12±4.25)pg/ml,卵泡刺激素(7.46±2.01)IU/L、促黄体生成素(5.31±0.22)IU/L低于对照组的(10.68±2.73)、(6.42±0.47)IU/L(P<0.05)。两组治疗后情感反应、身心关系、婚姻关系、社会关系、耐受性评分较本组治疗前显著下降,且观察组治疗后情感反应评分(1.34±0.15)分、身心关系评分(1.23±0.10)分、婚姻关系评分(1.16±0.09)分、社会关系评分(0.97±0.05)分、耐受性评分(0.86±0.07)分低于对照组的(1.67±0.28)、(1.78±0.21)、(1.80±0.24)、(1.33±0.12Objective To observe the effect of Kuntai capsule combined with hormone replacement therapy on patients with premature ovarian failure,so as to provide reference for clinical practice.Methods 70 patients with premature ovarian failure were randomly selected and divided into control group(35 cases)and observation group(35 cases)according to their order of admission.The control group was given hormone replacement therapy,and the observation group was given Kuntai capsule combined with hormone replacement therapy.Comparison was made on clinical symptom score,ovarian function,ovarian blood flow parameters,serum endocrine hormone and quality of life score before and after treatment between the two groups.Results After treatment,the scores of dizziness and tinnitus,lumbar debility and abnormal menstruation in both groups were significantly decreased compared with those before treatment;the scores of dizziness and tinnitus,lumbar debility and abnormal menstruation were(1.42±0.16),(1.39±0.14)and(1.24±0.17)points in the observation group,which were lower than(2.15±0.21),(2.63±0.20)and(2.10±0.11)points in the control group(P<0.05).After treatment,the number of antral follicle,ovarian volume and ovarian diameter in both groups increased significantly compared with those before treatment in this group;in the observation group,the number of antral follicle was(5.80±0.21),the ovarian volume was(6.65±0.51)cm^(3),and the ovarian diameter was(20.23±2.12)mm,which were greater than(3.71±0.30),(5.79±0.60)cm^(3),and(17.93±2.49)mm in the control group(P<0.05).After treatment,the bilateral ovarian blood flow velocity in both groups increased significantly compared with that before treatment in this group,and the resistance index and pulsatility index decreased significantly compared with those before treatment in this group;the observation group had greater bilateral ovarian blood flow velocity of(12.61±3.86)cm/s than(9.97±3.58)cm/s in the control group;the resistance index and pulsatility index were(0.59±0.10)and(0.63±

关 键 词：坤泰胶囊 激素替代治疗 卵巢早衰 卵巢功能 血清内分泌激素 

分 类 号：R711.75[医药卫生—妇产科学]