福州市鼓楼区儿童父母疫苗接种方案偏好属性调查研究  

A study on parental preferences for vaccination programs for their children in Gulou District of Fuzhou City

作　　者：张海荣 林光灿[1] 黄丽芳[1] ZHANG Hairong;LIN Guangcan;HUANG Lifang(Fujian Provincial Center for Disease Control and Prevention,Fuzhou,Fujian 350012,China)

机构地区：[1]福建省疾病预防控制中心,福建福州350012

出　　处：《海峡预防医学杂志》2024年第5期7-11,86,共6页Strait Journal of Preventive Medicine

基　　金：福建省卫生健康科技计划项目-中青年骨干人才培养项目(2020GGB020);中国乙肝防控科研基金项目(YGFK20210077)。

摘　　要：目的了解儿童父母疫苗接种方案的偏好属性,用离散选择实验(DCE)对接种剂次数、一般不良反应事件发生率、价格和疫苗来源进行评估。方法2023年6月11-15日,现场问卷调查福州市鼓楼区儿童父母,用混合logit模型估计儿童父母对不同疫苗接种方案的偏好,计算属性间的相对重要性,预测不同情境下的接种概率。结果调查儿童父母107人(82人纳入分析)。DCE实验结果显示,儿童父母更倾向于选择接种方案5剂次(六联苗+乙肝疫苗)、一般不良反应事件较少(发生率1/50)、进口疫苗和总费用800元的接种计划;4个属性中,儿童家长最看重的属性是接种方案剂次(β=3.203),其余属性由高到低依次为一般不良反应事件发生率低(β=2.539)、疫苗来源为进口(β=0.777)及总费用(β=0.230);以接种剂次为15剂次、一般不良反应事件发生率为1/10、总费用2800元、疫苗来源国产为参照时,当接种剂次为5剂次、一般不良反应事件发生率1/50、总费用800元、疫苗来源为进口时,儿童父母选择接种的可能性Pi会提高至100.0%。结论接种方案剂次数和一般不良反应事件发生率,是疫苗接种方案最重要的两个属性,可为研究今后免疫策略的优化和提高儿童疫苗的接种率,提供一定依据。Objective The aim of this study was to understand parents\preferences for vaccination programs for their children.Discrete Choice Experiment(DCE)was used to evaluate the number of doses,incidence of general adverse reactions,vaccine price,and vaccine sources.Methods From June 11 to June 15,2023,an on-site questionnaire survey was conducted among parents of children in Gulou District,Fuzhou City.A mixed logit model was used to estimate the preferences of children's parents for different vaccination regimens,calculate the relative importance between attributes,and predict the probability of vaccination in different contexts.Results A total of 107 parents were surveyed,82 of whom were included in the final analysis.The results of DCE analysis showed that children\s parents were more inclined to choose a vaccination program with 5 doses(hexavalent+Hepatitis B vaccine),fewer general adverse events(incidence rate 1/50),imported vaccines,and a total cost of 800 yuan.Among the four attributes,the most important attribute valued by children's parents was the number of doses in the vaccine program(β=3.203),and the remaining attributes,in descending order,were a low incidence of general adverse events(β=2.539),imported vaccine source(β=0.777),and total cost(β=0.230).Using a vaccination program with 15 doses,a 1/10 rate of general adverse events,a total cost of 2,800 yuan,and a domestic source of vaccine as a reference,the likelihood that parents would choose a vaccination program with 5 doses,a 1/50 rate of general adverse events,a total cost of 800 yuan,and an imported source of vaccine would increase to 100.0%.Conclusion The number of doses of a vaccination program and the incidence rate of general adverse events are the two most important attributes of a vaccination program.The results of this study can provide a basis for optimizing future immunization strategies and improving vaccination rates in children.

关 键 词：预防接种 离散选择实验(DCE) 儿童父母偏好 接种方案剂次数 疫苗接种率 

分 类 号：R186[医药卫生—流行病学]