尿毒症毒素血液灌流吸附剂的制备与性能  

Preparation and Properties of Hemoperfusion Adsorbent for Uremic Toxin Removal

作　　者：张玉坤 刘英姿 吴越 王为超 Yukun Zhang;Yingzi Liu;Yue Wu;Weichao Wang(Zibo Blood Purification Adsorbent Material Engineering Research Center,Zibo 255000,China;Zibo Kangbei Medical Co.,Ltd,Zibo 255000,China)

机构地区：[1]淄博市血液净化吸附材料工程技术研究中心,山东淄博255000 [2]淄博康贝医疗器械有限公司,山东淄博255000

出　　处：《高分子材料科学与工程》2024年第12期26-34,共9页Polymer Materials Science & Engineering

摘　　要：以苯乙烯和二乙烯苯为单体和架桥剂,加入2-苄基丙烯酸和甲基丙烯酸二乙基氨基乙基酯参与共聚反应,通过调整致孔剂用量和比例,采用悬浮聚合一步法制备了新型血液灌流吸附剂。通过N2吸附-脱附分析表征了吸附剂的孔结构,并进行了体外吸附实验、血液相容性实验研究吸附剂安全性和有效性。研究表明,此吸附材料的BET比表面积可达到582 m2/g,不仅具有大量的中孔,同时具有丰富的微孔,对多种尿毒症毒素具有较高吸附能力,血液学试验表现良好,有望于临床清除患者体内蛋白结合和中大分子毒素治疗尿毒症。The meticulously designed hemoperfusion adsorbent was synthesized employing one-step suspension polymerization,using harnessing styrene and divinylbenzene as constituent monomer and bridging agent.Critical to the process is the incorporation of 2-benzylacrylic acid and diethylaminoethyl methacrylate,which were strategically introduced to participate in the copolymerisation reaction.This was achieved through a methodical augmentation of the quantity and ratio of porogenic agent,a pivotal aspect of the synthesis.A thorough characterization of the intricate pore structure of adsorbent was conducted by N2 adsorption-desorption analysis.This was followed by a series of in vitro adsorption experiments and blood compatibility trials.These were undertaken with the specific aim of evaluating the safety and efficacy of the newly developed adsorbent.The results,which are both comprehensive and illuminating,reveal that the adsorbent exhibits a specific surface area of 582 m2/g.This is accompanied by a considerable quantity of mesopores and an extensive microporous region.Remarkably,the adsorbent demonstrates superlative adsorption efficiency for an array of toxins,ranging from medium to macromolecular toxins,and even extending to protein-bound toxins.Additionally,it displays laudable haemocompatibility.Consequently,these findings underscore the potential of this adsorbent as an effective option for blood perfusion treatment in patients suffering from uremia.

关 键 词：血液灌流 尿毒症毒素 吸附剂 中大分子毒素 蛋白结合毒素 

分 类 号：R318[医药卫生—生物医学工程]