基于数据挖掘探讨国家专利中药复方治疗眩晕用药规律  

Exploration on Medication Rules of National Patented Chinese Herbal Compounds for Treating Vertigo Based on Data Mining

作　　者：冯巧端 杨绍坤 唐洪彬 尤劲松[3] 张佛明[3] FENG Qiaoduan;YANG Shaokun;TANG Hongbin;YOU Jinsong;ZHANG Foming(The Second Clinical Medical School of Guangzhou University of Chinese Medicine,Guangzhou Guangdong 510405,China;West China School of Public Health,Sichuan University,Chengdu Sichuan 610041,China;Guangdong Provincial Hospital of Chinese Medicine,Guangzhou Guangdong 510120,China)

机构地区：[1]广州中医药大学第二临床医学院,广东广州510405 [2]四川大学华西公共卫生学院,四川成都610041 [3]广东省中医院,广东广州510120

出　　处：《新中医》2025年第3期1-8,共8页New Chinese Medicine

基　　金：国家中医药管理局“第七批全国老中医药专家学术经验继承项目”(国中医药人教函[2022]76号)。

摘　　要：目的:基于国家知识产权局专利检索及分析平台,通过数据挖掘技术分析中药复方治疗眩晕的用药规律。方法:收集国家知识产权局专利检索及分析平台中治疗眩晕的中药复方,使用Excel 2021软件对中药使用情况、性、味、归经和功效进行统计,运用R语言软件进行关联规则分析和系统聚类分析,使用Cytoscape软件构建中药复杂共现网络,借助MCODE插件进行聚类识别关键子网络。结果:共纳入中药复方357项,包含574味中药,用药总频次4 660次,使用频数≥30次的中药共40味,其中用药频次最高的为天麻。药物的性、味、归经和功效分析结果表明,药性以温、寒、平为主,药味以甘、苦、辛为主,多归肝、脾、心经,补虚药使用最频繁。关联规则分析结果显示,提升度排在前4位的角药组合为甘草-半夏-陈皮、茯苓-半夏-陈皮、白术-半夏-陈皮、天麻-陈皮-半夏。聚类分析得到5个药物组合,分别是白术-茯苓-泽泻-陈皮-半夏-甘草、钩藤-天麻、石菖蒲-丹参-葛根-川芎、党参-黄芪-当归、牛膝-牡蛎-柴胡-生地黄-菊花-白芍-枸杞子-夏枯草-熟地黄-山茱萸。共现网络分析结果显示,天麻、甘草、茯苓、白术、川芎和半夏为连接度较高的核心药物。非高频用药聚类识别关键子网络分析得出9个关联强度较高的药物组合。结论:治疗眩晕应以补益脾肾、平肝息风、利湿活血为重要治则,重视天麻、甘草、茯苓、白术、半夏等关键中药的配伍。Objective:To analyze the medication rules of Chinese herbal compounds for treating vertigo by data mining techniques based on the patent search and analysis platform of the China National Intellectual Property Administration.Methods:Chinese herbal compounds for treating vertigo were collected from the patent search and analysis platform of the China National Intellectual Property Administration.The usage,natures and flavors,meridian entries,and efficacy of the Chinese medicinals were statistically analyzed using Excel 2021.Association rule analysis and hierarchical cluster analysis were performed using R software.A complex co-occurrence network of Chinese medicinals was constructed using Cytoscape software,and key subnetworks were identified with the MCODE plugin.Results:A total of 357 Chinese herbal compounds were included,comprising 574 different Chinese medicinals with a total usage frequency of 4660 times.Among these,40 Chinese medicinals had a usage frequency of 30 times or more,with Gastrodiae Rhizoma being the most frequently used.Analysis of the natures,flavors,meridian entries,and efficacy of the Chinese medicinals showed that warm,cold and neutral properties were predominant,with sweet,bitter,and acrid flavors being the most common.The Chinese medicinals mainly targeted the liver,spleen,and heart meridians,with deficiency-supplementing herbs being the most frequently used.Association rule analysis revealed that the top four triplet medicinals with the highest lift were Glycyrrhizae Radix et Rhizoma-Pinelliae Rhizoma-Citri Reticulatae Pericarpium,Poria-Pinelliae Rhizoma-Citri Reticulatae Pericarpium,Atractylodis Macrocephalae Rhizoma-Pinelliae Rhizoma-Citri Reticulatae Pericarpium,and Gastrodiae Rhizoma-Citri Reticulatae Pericarpium-Pinelliae Rhizoma.Five drug combinations were obtained by cluster analysis,namely Atractylodis Macrocephalae Rhizoma-Poria-Alismatis Rhizoma-Citri Reticulatae Pericarpium-Pinelliae Rhizoma-Glycyrrhizae Radix et Rhizoma,Uncariae Ramulus cum Uncis-Gastrodiae Rhizoma,Acori Tatar

关 键 词：眩晕 中药复方 国家专利 数据挖掘 用药规律 

分 类 号：R255.3[医药卫生—中医内科学]