基于数据挖掘探讨滕秀香运用补肾理脾疏肝法治疗卵巢储备功能减退用药规律  

Exploring Medication Rules of TENG Xiuxiang Using Method of Supplementing Kidney,Regulating Spleen,and Soothing Liver to Treat Ovarian Reserve Dysfunction Based on Data Mining

作　　者：刘珍珍 张雨晴 陈梦园 游瑾渝 蔡梦琴 王一迪 滕秀香[2] LIU Zhenzhen;ZHANG Yuqing;CHEN Mengyuan;YOU Jinyu;CAI Mengqin;WANG Yidi;TENG Xiuxiang(Bao′an Authentic Traditional Chinese Medicine Therapy Hospital,Shenzhen Guangdong 518101,China;Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing 100010,China)

机构地区：[1]深圳市宝安纯中医治疗医院,广东深圳518101 [2]首都医科大学附属北京中医医院,北京100010

出　　处：《新中医》2025年第3期17-22,共6页New Chinese Medicine

基　　金：首都卫生发展科研专项(首发2022-2-2233)。

摘　　要：目的:基于数据挖掘探讨滕秀香教授运用补肾理脾疏肝法治疗卵巢储备功能减退(DOR)用药规律。方法:收集2017年12月—2022年12月滕秀香教授门诊治疗的DOR患者有效病例处方326首,基于Excel2019软件统计处方使用药物、功效、性味归经、频次,基于SPSS modeler 18.0 Apriori算法进行高频药物关联规则分析,基于Cytoscape3.9.1软件进行复杂网络分析,基于SPSS statistics 28.0进行高频药物R型聚类分析。结果:共收录处方326首中药处方,涉及中药126味,高频使用药物30味;主要药类为补虚药、活血化瘀药、解表药及利水渗湿药;药性平、微寒为主,药味甘、苦、辛为主,归肝、肾、肺、脾、胃、心经;高频关联药对30组;处方核心药物菟丝子、太子参、柴胡、续断、丹参、黄精、酒白芍、桑寄生、甘草;核心药对“菟丝子-太子参-柴胡”;组方类别9类。结论:滕秀香教授将DOR分为两种基本病机:肝肾阴虚证、脾肾阳虚证,及四种兼夹病机:肝郁、血热、湿浊、血瘀,基本治法为补肾理脾疏肝、清热利湿化瘀。Objective:To explore Professor TENG Xiuxiang′s medication rules in the application of the method of supplementing kidney,regulating spleen,and soothing liver to treat ovarian reserve dysfunction(DOR)based on data mining.Methods:A total of 326 effective prescriptions for DOR patients treated in Professor TENG Xiuxiang′s outpatient department from December 2017 to December 2022 were collected.Medicinals in the prescriptions and their efficacy,nature,flavors,entries of meridians,and usage frequency were statistically analyzed using Excel 2019 software.Association rule analysis of high-frequency medicinals was performed using SPSS modeler 18.0 Apriori algorithm;complex network analysis was performed using Cytoscape 3.9.1 software;R-type clustering analysis of high-frequency medicinals was performed using SPSS statistics 28.0.Results:A total of 326 Chinese medicine prescriptions were included,involving 126 Chinese medicinals and 30 high-frequency medicinals;the main types of medicinals were for supplementing deficiency,invigorating blood and dissolving stasis,releasing the exterior,and promoting urination and percolating dampness.The main medicinal nature was neutral and slightly cold,with sweetness,bitterness,and pungency as the main medicinal flavors.The main entries of meridians were the liver,kidney,lung,spleen,stomach,and heart meridians.There were 30 high-frequency associated medicinal couplets.Core medicinals included Cuscutae Semen,Pseudostellariae Radix,Bupleuri Radix,Dipsaci Radix,Salviae Miltiorrhizae Radix et Rhizoma,Polygonati Rhizoma,wine-fried Paeoniae Radix Alba,Taxilli Herba,and Glycyrrhizae Radix et Rhizoma.The core medicinal couple was"Cuscutae Semen-Pseudostellariae Radix-Bupleuri Radix".There were nine types of prescriptions.Conclusion:Professor TENG Xiuxiang divides the pathological mechanisms of DOR into two basic types,namely the liver-kidney yin deficiency syndrome and the spleen-kidney yang deficiency syndrome,with four concurrent pathological mechanisms including liver depression,blood h

关 键 词：卵巢储备功能减退 数据挖掘 用药规律 补肾理脾疏肝 滕秀香 

分 类 号：R271.9[医药卫生—中西医结合]