苏子降气汤合三子养亲汤联合常规疗法治疗痰浊阻肺型慢性阻塞性肺疾病急性加重期临床研究  

Clinical Study on Suzi Jiangqi Decoction and Sanzi Yangqin Decoction Combined with Conventional Therapy for Acute Exacerbation of Chronic Obstructive Pulmonary Disease of Phlegm Turbidity Obstructing the Lung Type

作　　者：梁芹芹 叶蒙娇 LIANG Qinqin;YE Mengjiao(Zhejiang Chinese Medical University,Hangzhou Zhejiang 310053,China;Department of Respiratory and Critical Care Medicine,Tiantai Hospital of Traditional Chinese Medicine,Tiantai Zhejiang 317203,China)

机构地区：[1]浙江中医药大学,浙江杭州310053 [2]天台县中医院呼吸与危重症医学科,浙江天台317203

出　　处：《新中医》2025年第3期28-33,共6页New Chinese Medicine

摘　　要：目的:观察苏子降气汤合三子养亲汤联合常规疗法治疗痰浊阻肺型慢性阻塞性肺疾病急性加重期(AECOPD)的临床疗效。方法:选取2021年9月—2023年11月天台县中医院收治的102例AECOPD痰浊阻肺证患者,按照随机数字表法分为试验组和对照组各51例。试验组以苏子降气汤合三子养亲汤联合常规疗法治疗,对照组仅给予常规疗法治疗,2组均治疗1周。比较2组临床疗效、中医证候积分、肺功能[第1秒用力呼气容积(FEV_(1))、用力肺活量(FVC)、FEV_(1)/FVC值]、动脉血血气指标[血氧分压(PaO_(2))、二氧化碳分压(PaCO_(2))]及血清炎症因子指标[C-反蛋白(CRP)、前降钙素(PCT)、白细胞计数(WBC)]。结果:治疗后,试验组总有效率93.88%(46/49),优于对照组79.17%(38/48)(P<0.05)。2组中医证候积分均较治疗前降低(P<0.05),试验组中医证候积分低于对照组(P<0.05)。2组FEV_(1)、FVC、FEV_(1)/FVC值均较治疗前提高(P<0.05),试验组FEV_(1)、FVC、FEV_(1)/FVC值均高于对照组(P<0.05)。2组PaO_(2)水平均较治疗前升高(P<0.05),PaCO_(2)水平均较治疗前降低(P<0.05);2组PaO_(2)、PaCO_(2)水平比较,差异均无统计学意义(P>0.05)。2组CRP、PCT、WBC水平均较治疗前降低,试验组CRP、PCT、WBC水平均低于对照组(P<0.05)。结论:苏子降气汤合三子养亲汤联合常规疗法治疗AECOPD痰浊阻肺证临床疗效优于常规疗法,缓解症状、改善肺功能、减轻炎症更为显著,改善动脉血血气指标效果与常规疗法一致。Objective:To observe the clinical effect of the therapy of Suzi Jiangqi Decoction and Sanzi Yangqin Decoction combined with conventional therapy on acute exacerbation of chronic obstructive pulmonary disease(AECOPD)of phlegm turbidity obstructing the lung type.Methods:A total of 102 AECOPD patients of phlegm turbidity obstructing the lung type admitted to Tiantai Hospital of Traditional Chinese Medicine from September 2021 to November 2023 were selected and divided into the trial group and the control group according to the random number table method,with 51 cases in each group.The trial group was treated with Suzi Jiangqi Decoction and Sanzi Yangqin Decoction combined with conventional therapy and the control group was only treated with conventional therapy.The two groups were treated for one week.The clinical effects,traditional Chinese medicine(TCM)syndrome scores,lung function indexes[forced expiratory volume in one second(FEV_(1)),forced vital capacity(FVC)and FEV_(1)/FVC],arterial blood gas indexes[partial pressure of oxygen(PaO_(2))and partial pressure of carbon dioxide(PaCO_(2))]and serum inflammatory factors[C-reactive protein(CRP),procalcitonin(PCT)and white blood cell count(WBC)]were compared between the two groups Results:After treatment,the total effective rate was 93.88%(46/49)in the trial group,higher than that of 79.17%(38/48)in the control group(P<0.05).The TCM syndrome scores in the two groups were reduced when compared with those before treatment(P<0.05),and the above scores in the trial group was lower than that in the control group(P<0.05).The levels of FEV_(1),FVC and FEV_(1)/FVC in the two groups were elevated when compared with those before treatment(P<0.05),and the above three indexes in the trial group were higher than those in the control group(P<0.05).The PaO_(2) levels in the two groups were up-regulated when compared with those before treatment(P<0.05),and the PaCO_(2) levels were down-regulated when compared with those before treatment(P<0.05);there were no significant differences b

关 键 词：慢性阻塞性肺疾病急性加重期 痰浊阻肺证 苏子降气汤 三子养亲汤 肺功能 血气指标 炎症因子 

分 类 号：R563[医药卫生—呼吸系统]