滋肾疏肝方联合雌孕激素序贯疗法治疗肾虚肝郁型卵巢早衰临床研究  

Clinical Study on Zishen Shugan Prescription Combined with Sequential Therapy of Estrogen and Progesterone for Premature Ovarian Failure of Kidney Deficiency and Liver Constraint Type

作　　者：陈英华 CHEN Yinghua(Department of Gynaecology and Obstertrics,General Hospital of Pingmei Shenma Group,Pingdingshan Henan 467000,China)

机构地区：[1]平煤神马医疗集团总医院妇产科,河南平顶山467000

出　　处：《新中医》2025年第3期90-94,共5页New Chinese Medicine

摘　　要：目的:观察滋肾疏肝方联合雌孕激素序贯疗法治疗肾虚肝郁型卵巢早衰的临床效果。方法:采用随机数字表法将2021年1月—2023年12月平煤神马医疗集团总医院收治的86例肾虚肝郁型卵巢早衰患者分为对照组、观察组各43例。对照组给予雌孕激素序贯疗法治疗,观察组在对照组基础上加用滋肾疏肝方治疗,2组均治疗6周。比较2组治疗前后中医证候评分、卵巢体积、窦卵泡数及性激素水平;比较2组临床疗效及不良反应发生率。结果:观察组总有效率88.37%(38/43),高于对照组69.77%(30/43)(P<0.05)。治疗后,2组中医证候评分及血清卵泡刺激素(FSH)、黄体生成激素(LH)水平均较治疗前降低(P<0.05),E2水平升高(P<0.05),卵巢体积增大(P<0.05),窦卵泡数增加(P<0.05);观察组治疗后中医证候积分及血清FSH、LH水平低于对照组,E2水平高于对照组(P<0.05),卵巢体积大于对照组(P<0.05),窦卵泡数多于对照组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:滋肾疏肝方联合雌孕激素序贯疗法治疗肾虚肝郁型卵巢早衰疗效确切,能够调节患者性激素水平及改善卵巢功能,安全性较高。Objective:To observe the clinical effect of the combination use of Zishen Shugan Prescription and sequential therapy of estrogen and progesterone on premature ovarian failure of kidney deficiency and liver constraint type.Methods:A total of 86 patients with premature ovarian failure of kidney deficiency and liver constraint type admitted to General Hospital of Pingmei Shenma Group from January 2021 to December 2023 were divided into the control group and the observation group by the random number table method,with 43 cases in each group.The control group was treated with sequential therapy of estrogen and progesterone,and the observation group was treated with Zishen Shugan Decoction based on the treatment of the control group.Both groups were treated for six weeks.The traditional Chinese medicine(TCM)syndrome scores,ovarian volume,antral follicle count and the levels of sex hormones before and after treatment,and the clinical effects and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate was 88.37%(38/43)in the observation group,higher than that of 69.77%(30/43)in the control group(P<0.05).After treatment,the TCM syndrome scores and the levels of serum follicle stimulating hormone(FSH)and luteinizing hormone(LH)in the two groups were dwindled when compared with those before treatment(P<0.05),and the E2 levels,ovarian volume and the number of antral follicles were elevated(P<0.05);after treatment,the TCM syndrome scores and the levels of serum FSH and LH in the observation group were lower than those in the control group(P<0.05),and the E2 level,ovarian volume and the number of antral follicles were respectively higher than those in the control group(P<0.05).There was no significant difference being found in the comparison of the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The combination use of Zishen Shugan Prescription and sequential therapy of estrogen and progesterone has a definite curative effect on premature ovarian failure

关 键 词：卵巢早衰 肾虚肝郁 雌孕激素序贯疗法 滋肾疏肝方 性激素 

分 类 号：R711.51[医药卫生—妇产科学]