妇科千金片联合阿奇霉素治疗急性盆腔炎临床研究  

Clinical Study on Combination Use of Fuke Qianjin Tablets and Azithromycin for Acute Pelvic Inflammatory Disease

作　　者：周金玲 孙成艳 徐晓聪 ZHOU Jinling;SUN Chengyan;XU Xiaocong(Yongkang No.2 People Hospital,Yongkang Zhejiang 321300,China)

机构地区：[1]永康市第二人民医院,浙江永康321300

出　　处：《新中医》2025年第3期95-99,共5页New Chinese Medicine

摘　　要：目的:观察妇科千金片联合阿奇霉素治疗急性盆腔炎的疗效及对子宫血流动力学、免疫学指标的影响。方法:选取2020年11月—2022年11月永康市第二人民医院收治的70例急性盆腔炎患者,按随机数字表法分为试验组及对照组各35例。对照组采用阿奇霉素治疗,试验组在对照组基础上服用妇科千金片治疗。比较2组临床疗效及不良反应发生率,比较2组治疗前后McCormack量表评分、炎性包块、盆腔积液、子宫血流动力学指标[阻力指数(RI)、搏动指数(PI)、平均血流速度(Vmin)]、免疫学指标值的变化。结果:试验组临床疗效总有效率为94.29%(33/35),对照组为77.14%(27/35),2组比较,差异有统计学意义(P<0.05)。治疗后,2组McCormack量表评分、炎性包块、盆腔积液均较治疗前减小(P<0.05),试验组McCormack量表评分、炎性包块、盆腔积液均小于对照组(P<0.05)。治疗后,2组RI、PI值均较治疗前下降(P<0.05),Vmin值均较治疗前升高(P<0.05);试验组RI、PI值均低于对照组(P<0.05),Vmin值高于对照组(P<0.05)。治疗后,2组CD4^(+)水平、CD4^(+)/CD8^(+)比值均较治疗前上升(P<0.05),CD8^(+)水平均较治疗前下降(P<0.05);试验组CD4^(+)水平、CD4^(+)/CD8^(+)比值均高于对照组,CD8^(+)水平低于对照组(P<0.05)。试验组不良反应发生率为5.71%(12/35),对照组不良反应发生率为8.57%(3/35),2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:妇科千金片联合阿奇霉素治疗急性盆腔炎效果较好,可改善患者子宫血流动力学指标,提高免疫功能,安全性高。Objective:To observe the curative effect of the combination use of Fuke Qianjin Tablets and Azithromycin on acute pelvic inflammatory disease and its effect on uterine hemodynamics and immunology indexes.Methods:A total of 70 patients with acute pelvic inflammatory disease admitted to Yongkang No.2 People Hospital from November 2020 to November 2022 were selected and divided into the trial group and the control group according to the random number table method,with 35 cases in each group.The control group was treated with Azithromycin,and the trial group was additionally treated with Fuke Qianjin Tablets based on the treatment of the control group.The clinical effects and incidence of adverse reactions,and the changes of scores of McCormack Scale,inflammatory mass,pelvic effusion,uterine hemodynamics indexes[resistance index(RI),pulsatility index(PI)and mean blood flow velocity(Vmin)]and immunology indexes before and after treatment were compared between the two groups.Results:The total effective rate was 94.29%(33/35)in the trial group and 77.14%(27/35)in the control group,the difference being significant(P<0.05).After treatment,the scores of McCormack Scale,inflammatory mass and pelvic effusion in the two groups were reduced when compared with those before treatment(P<0.05),and the score of McCormack scale,inflammatory mass and pelvic effusion in the trial group were less than those in the control group(P<0.05).After treatment,the values of RI and PI in the two groups were decreased when compared with those before treatment(P<0.05),and the Vmin values were elevated when compared with those before treatment(P<0.05);the values of RI and PI in the trial group were lower than those in the control group(P<0.05),and the Vmin value was higher than that in the control group(P<0.05).After treatment,the CD4^(+)levels and CD4^(+)/CD8^(+)ratio in the two groups were up-regulated when compared with those before treatment(P<0.05),and the CD8^(+)levels were down-regulated when compared with those before treatment(P<0.05);the

关 键 词：急性盆腔炎 湿毒壅盛型 妇科千金片 阿奇霉素 子宫血流动力学 

分 类 号：R711.33[医药卫生—妇产科学]