疏肝利胆方联合理气通腑散外敷对急性胆囊炎炎症反应及胃肠功能的影响  

Effect of Shugan Lidan Prescription Combined with External Application with Liqi Tongfu Powder on Inflammatory Responses and Gastrointestinal Function in Acute Cholecystitis

作　　者：林珍艺 邵恩惠 LIN Zhenyi;SHAO Enhui(Department of Surgery,Wenling Hospital of Traditional Chinese Medicine,Wenling Zhejiang 317500,China)

机构地区：[1]温岭市中医院外科,浙江温岭317500

出　　处：《新中医》2025年第3期162-166,共5页New Chinese Medicine

摘　　要：目的:观察疏肝利胆方联合理气通腑散外敷对急性胆囊炎炎症反应及胃肠功能的影响。方法:选择2023年1—12月温岭市中医院收治的104例急性胆囊炎患者,按随机数字表法分为研究组及对照组各52例。2组均接受腹腔镜胆囊切除术,对照组术后接受常规现代医学治疗,研究组在常规现代医学治疗基础上给予疏肝利胆方联合理气通腑散外敷。治疗7 d后比较2组临床疗效,比较2组治疗前后中医证候积分、胃肠功能恢复时间及炎症因子[C-反应蛋白(CRP)、白细胞介素-6 (IL-6)、白细胞介素-1β (IL-1β)]水平的变化。结果:研究组临床疗效总有效率为96.15%(50/52),对照组临床疗效总有效率为82.69%(43/52),2组比较,差异有统计学意义(P<0.05)。治疗后,2组中医证候主症、次症及总积分均较治疗前下降(P<0.05),研究组中医证候主症、次症及总积分均低于对照组(P<0.05)。研究组肠鸣音恢复时间、腹痛消失时间、首次排气时间、排便时间均短于对照组,差异均有统计学意义(P<0.05)。治疗后,2组CRP、IL-6、IL-1β水平均较治疗前下降(P<0.05),研究组上述3项水平均低于对照组(P<0.05)。结论:疏肝利胆方联合理气通腑散外敷治疗急性胆囊炎疗效较好,可加快术后胃肠功能恢复,减轻炎症反应。Objective:To observe the effect of Shugan Lidan Prescription combined with external application with Liqi Tongfu Powder on inflammatory responses and gastrointestinal function in acute cholecystitis.Methods:A total of 104 patients with acute cholecystitis admitted to Wenling Hospital of Traditional Chinese Medicine from January to December 2023 were divided into the study group and the control group by random number table method,with 52 patients in each group.Both groups underwent laparoscopic cholecystectomy;the control group received routine modern medical treatment after surgery,and the study group received Shugan Lidan Prescription combined with external application with Liqi Tongfu Powder on the basis of routine modern medical treatment.Compared the clinical efficacy in the two groups after seven days of treatment,and compared the changes in traditional Chinese medicine syndrome scores,gastrointestinal function recovery,and levels of inflammatory factors[C-reactive protein(CRP),interleukin-6(IL-6),and interleukin-1β(IL-1β)]before and after treatment.Results:The total effective rate of clinical efficacy was 96.15%(50/52)in the study group,and 82.69%(43/52)in the control group,the difference being significant(P<0.05).After treatment,the main symptoms,secondary symptoms,and total scores of traditional Chinese medicine syndromes in both groups were decreased when compared with those before treatment(P<0.05).The main symptoms,secondary symptoms,and total scores of traditional Chinese medicine syndromes in the study group were lower than those in the control group(P<0.05).The recovery time of bowel sounds,disappearance time of abdominal pain,the first exhaust time,and defecation time in the study group were all shorter than those in the control group,differences being significant(P<0.05).After treatment,the levels of CRP,IL-6,and IL-1βin both groups were decreased when compared with those before treatment(P<0.05),and the above three levels in the study group were lower than those in the control group(P<0.05).Co

关 键 词：急性胆囊炎 腹腔镜胆囊切除术 疏肝利胆方 理气通腑散 炎症反应 胃肠功能 

分 类 号：R248.2[医药卫生—中医临床基础]