交感维持性疼痛发病机制的研究进展  

Research Progress in Pathogenesis of Sympathetically Maintained Pain

作　　者：韩锡存 蒋晓华 刘亚彬 陈国武[2] HAN Xicun;JIANG Xiaohua;LIU Yabin;CHEN Guowu(Jining Medical University,Jining 272000,China;Department of Spine Surgery,Affiliated Hospital of Jining Medical University,Jining 272000,China)

机构地区：[1]济宁医学院,山东济宁272000 [2]济宁医学院附属医院脊柱外科,山东济宁272000

出　　处：《医学综述》2025年第5期523-528,共6页Medical Recapitulate

基　　金：济宁市重点研发计划项目(2021YXNS051);贺林院士新医学临床转化工作站科研基金面上项目(JYHL2021FMS10);济宁医学院附属医院博士科研基金项目(2022-BS-009)。

摘　　要：交感维持性疼痛(SMP)是一种与交感神经系统异常活动紧密相关的疼痛状态,这种状态常见于复杂区域疼痛综合征。SMP的发病机制涉及多个关键因素,包括交感神经与伤害性感觉神经元之间的异常耦合、肾上腺素能受体的上调、去甲肾上腺素转运体的变化、神经元兴奋性的改变、神经营养因子的参与,以及胶质细胞和ATP的作用,这些因素相互作用,共同促进SMP的发展。但目前对于其发病机制的了解仍不完全成熟,且存在一些争议和未解决的问题,有待深入研究。Sympathetically maintained pain(SMP)is a pain state closely associated with abnormal activity of the sympathetic nervous system,commonly seen in complex regional pain syndrome.The pathogenesis of SMP involves several key factors,including abnormal coupling between sympathetic nerves and nociceptive sensory neurons,upregulation of adrenergic receptors,changes in the norepinephrine transporter,alterations in neuronal excitability,involvement of neurotrophic factors and the role of glial cells and adenosine triphosphate.These factors interact with each other,contributing to the development of SMP.However,the current understanding of its pathogenesis is still not fully mature,and there are some disputes and unresolved problems,which need to be further studied.

关 键 词：交感维持性疼痛 交感神经系统 神经病理性痛 背根神经节 交感神经芽生 

分 类 号：R338[医药卫生—人体生理学]