血清髓过氧化物酶与动脉粥样硬化性疾病相关性的研究进展  

Research Progress of Association between Serum Myeloperoxidase and Atherosclerotic Diseases

作　　者：阿迪拉·吾拉穆 李小雷 马依彤[1] 阿迪拉·阿扎提[1] ADILA Wulamu;LI Xiaolei;MA Yitong;ADILA Azhati(Department of Cardiovascular Medicine,the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,China)

机构地区：[1]新疆医科大学第一附属医院心血管内科,乌鲁木齐830054

出　　处：《医学综述》2025年第5期536-541,共6页Medical Recapitulate

基　　金：新疆维吾尔自治区天山英才科技创新领军人才项目(2022TSYCLJ0067)。

摘　　要：髓过氧化物酶(MPO)是血红素过氧化物酶家族成员,由中性粒细胞和巨噬细胞分泌。近年MPO在心血管疾病中的作用受到广泛关注。其中,动脉粥样硬化(As)为一种多因素参与的慢性心血管疾病,MPO引发的氧化应激和炎症反应在As内皮功能早期受损、斑块形成以及斑块的破裂中发挥关键作用,且贯穿疾病的整个病理过程。因此,深入研究MPO在As中的作用机制具有重要的临床意义。Myeloperoxidase(MPO),a member of the heme peroxidase family,is secreted by neutrophils and macrophages.Its function attention in the field of cardiovascular diseases has received extensive in recent years.Among them,atherosclerosis(As)is a chronic cardiovascular disease involving multiple factors.Oxidative stress and inflammation induced by MPO play a key role in the early impairment of endothelial function,plaque formation and plaque rupture of As,and run through the entire pathological process of the disease.Therefore,it is of great clinical significance to further study the mechanism of MPO in As.

关 键 词：动脉粥样硬化性疾病 血清髓过氧化物酶 药物干预靶点 

分 类 号：R543.5[医药卫生—心血管疾病]