非吸烟相关慢性阻塞性肺疾病致病因素的研究进展  

Research Progress of Pathogenic Factors for Non-Smoking Related Chronic Obstructive Pulmonary Disease

作　　者：孙伟 何燕超 SUN Wei;HE Yanchao(Department of Internal Medicine,Maternal and Child Health Hospital of Jiangxia District,Wuhan 430200,China;Department of Respiratory Critical Care Medicine,the First People's Hospital of Jiangxia District,Wuhan 430200,China)

机构地区：[1]武汉市江夏区妇幼保健院内科,武汉430200 [2]武汉市江夏区第一人民医院呼吸危重症医学科,武汉430200

出　　处：《医学综述》2025年第5期574-578,583,共6页Medical Recapitulate

基　　金：武汉市医学科学研究面上项目(WX23A87);武汉市江夏区第一人民医院面上科研项目(2023JXYYMS007)。

摘　　要：非吸烟相关慢性阻塞性肺疾病(COPD)是一种病理生理学疾病,可继发于不同的肺部疾病或由不同的致病因素引发。COPD发病机制复杂,可能涉及环境因素、遗传因素、感染因素以及生活方式等。因此,全面了解COPD的致病因素、明确其发病机制具有重要意义。基因缺陷和肺发育异常等遗传因素、室内外环境污染和职业暴露等环境因素以及结核杆菌和人类免疫缺陷病毒感染等感染因素均与COPD相关。未来,深入研究非吸烟相关COPD的致病因素及作用机制,可以为疾病的治疗提供新思路。Non-smoking related chronic obstructive pulmonary disease(COPD)is a pathophysiological disease that can result from different lung diseases or be caused by different pathogenic factors.The pathogenesis of COPD is complex and may involve environmental factors,genetic factors,infection factors,and lifestyle factors.Thus,gaining a thorough understanding of the pathogenic factors of COPD and elucidating its pathogenesis is of great importance.Genetic factors including genetic defects and aberrant lung development,environmental factors,such as indoor and outdoor air pollution and occupational exposures,and infectious factors,including Mycobacterium tuberculosis and human immunodeficiency virus infections,are all associated with COPD.In the future,in-depth research on the pathogenic factors and mechanisms of non-smoking related COPD can provide new ideas for the therapeutic approaches.

关 键 词：慢性阻塞性肺疾病 非吸烟人群 致病因素 

分 类 号：R563.3[医药卫生—呼吸系统]