Personalized bioceramic grafts for craniomaxillofacial bone regeneration  

作　　者：Ana Beatriz G.de Carvalho Maedeh Rahimnejad Rodrigo L.M.S.Oliveira Prabaha Sikder Guilherme S.F.A.Saavedra Sarit B.Bhaduri Debby Gawlitta Jos Malda Darnell Kaigler Eliandra S.Trichês Marco C.Bottino 

机构地区：[1]Department of Cariology,Restorative Sciences and Endodontics,School of Dentistry,University of Michigan,Ann Arbor,MI,USA [2]Department of Dental Materials and Prosthodontics,São Paulo State University,São Josédos Campos,SP,Brazil [3]Federal University of São Paulo,Institute of Science and Technology,São Josédos Campos,SP,Brazil [4]Department of Mechanical Engineering,Cleveland State University,Cleveland,OH,USA [5]Department of Mechanical,Industrial and Manufacturing Engineering,University of Toledo,Toledo,OH,USA [6]Department of Oral and Maxillofacial Surgery&Special Dental Care,University Medical Center Utrecht,Utrecht University,Utrecht,The Netherlands [7]Regenerative Medicine Center Utrecht,Utrecht,The Netherlands [8]Department of Clinical Sciences,Faculty of Veterinary Medicine,Utrecht University,Utrecht,The Netherlands [9]Department of Orthopedics,University Medical Center Utrecht,Utrecht,The Netherlands [10]Department of Periodontics and Oral Medicine,School of Dentistry,University of Michigan,Ann Arbor,MI,USA [11]Department of Biomedical Engineering,College of Engineering,University of Michigan,Ann Arbor,MI,USA

出　　处：《International Journal of Oral Science》2024年第4期575-599,共25页国际口腔科学杂志(英文版)

基　　金：supported by funding from the National Institutes of Health(NIH),National Institute of Dental and Craniofacial Research[R01DE031476 to MCB];the São Paulo Research Foundation(FAPESP,projects 2022/03811-9 to ABGC;2021/05259-9 to RLMSO;and 2022/12217-3 to EST);The content is solely the authors’responsibility and does not necessarily represent the official views of the National Institutes of Health。

摘　　要：The reconstruction of craniomaxillofacial bone defects remains clinically challenging.To date,autogenous grafts are considered the gold standard but present critical drawbacks.These shortcomings have driven recent research on craniomaxillofacial bone reconstruction to focus on synthetic grafts with distinct materials and fabrication techniques.Among the various fabrication methods,additive manufacturing(AM)has shown significant clinical potential.AM technologies build three-dimensional(3D)objects with personalized geometry customizable from a computer-aided design.These layer-by-layer 3D biomaterial structures can support bone formation by guiding cell migration/proliferation,osteogenesis,and angiogenesis.Additionally,these structures can be engineered to degrade concomitantly with the new bone tissue formation,making them ideal as synthetic grafts.This review delves into the key advances of bioceramic grafts/scaffolds obtained by 3D printing for personalized craniomaxillofacial bone reconstruction.In this regard,clinically relevant topics such as ceramic-based biomaterials,graft/scaffold characteristics(macro/micro-features),material extrusion-based 3D printing,and the step-by-step workflow to engineer personalized bioceramic grafts are discussed.Importantly,in vitro models are highlighted in conjunction with a thorough examination of the signaling pathways reported when investigating these bioceramics and their effect on cellular response/behavior.Lastly,we summarize the clinical potential and translation opportunities of personalized bioceramics for craniomaxillofacial bone regeneration.

关 键 词：PRINTING SHORTCOMINGS ceramic 

分 类 号：R318.08[医药卫生—生物医学工程]