四联活菌片联合神曲消食口服液对功能性腹痛患儿胃动素和P物质的影响  

Effect of four active bacteria tablets combined with shenqu xiaoshi oral liquid on motilin and substance P in children with functional abdominal pain

作　　者：黄永玲 张军红 陈宥杨 HUANG Yongling;ZHANG Junhong;CHEN Youyang(Department of Pediatrics,Jingmen Central Hospital,Jingmen Central Hospital Affiliated to Jingchu University of Technology,Hubei Jingmen 448000,China)

机构地区：[1]荆门市中心医院,荆楚理工学院附属荆门市中心医院儿科,湖北荆门448000

出　　处：《临床药物治疗杂志》2024年第12期76-82,共7页Clinical Medication Journal

摘　　要：目的探讨四联活菌片联合神曲消食口服液对功能性腹痛患儿胃动素和P物质的影响。方法选取2021年3月至2023年2月湖北省荆门市中心医院收治的功能性腹痛患儿为研究对象,将患儿分为观察组和对照组。对照组口服神曲消食口服液,观察组在对照组治疗基础上口服四联活菌片,两组均连续治疗14 d。通过倾向性评分匹配法按照1∶1匹配后两组各为60例,比较两组患儿一般资料、治疗前后胃动素与P物质水平及临床疗效。采用广义估计方程(GEE)模型分析不同治疗方式对两组患儿胃动素和P物质水平的影响;利用logistic回归模型分析治疗7、14 d后的胃动素和P物质与功能性腹痛患儿治疗后疗效不好的关系;并采用非条件logistic回归模型分析治疗7、14 d后胃动素和P物质对功能性腹痛患儿治疗后疗效的相乘交互作用。结果共纳入150例患儿,采用倾向性评分匹配法按1∶1匹配后,两组各60例。观察组总有效率高于对照组(90.00%比73.33%),差异有统计学意义(P<0.05);两组患儿治疗后胃动素及P物质水平较治疗前均明显降低,且观察组患儿胃动素及P物质水平低于对照组患儿(P<0.05);重复测量方差分析显示,两组患儿胃动素及P物质的时间效应、组间效应和交互效应比较,差异均有统计学意义(P<0.05);GEE分析显示,观察组治疗方式对胃动素和P物质水平的影响较大(P<0.05);校正混杂因素后,治疗7、14 d后胃动素和P物质与功能性腹痛患儿疗效呈正相关;交互作用分析显示,相乘模型与相加模型中,治疗7、14 d后胃动素和P物质对功能性腹痛患儿发生疗效的影响均存在交互作用。结论四联活菌片联合神曲消食口服液能有效降低胃动素和P物质水平,调节胃肠激素水平进而治疗功能性腹痛。Objective To investigate the effects of four active bacteria tablets combined with Shenqu Xiaoshi oral liquid on motilin and substance P in children with functional abdominal pain.Methods Children with functional abdominal pain admitted to Jingmen Central Hospital of Hubei Province from March 2021 to February 2023 were selected as the study objects,and were divided into observation group and control group.The control group was treated with Shenqu Xiaoshi oral liquid,and the observation group was treated with quadruple viable bacteria tablets on the basis of the treatment of the control group.Both groups were treated for 14 consecutive days.There were 60 cases in each group after 1∶1 matching by propensity score matching method.The general data and the levels of motilin and substance P before and after treatment and the clinical efficacy of the two groups were compared.The generalized estimation equation(GEE)model was used to analyze the effects of different treatment methods on the levels of motilin and substance P in the two groups.logistic regression model was used to analyze the relationship between motilin,substance P and poor therapeutic effect in children with functional abdominal pain after 7 and 14 days of treatment.Unconditional logistic regression model was used to analyze the multiplicative interaction of motilin and substance P on the therapeutic effect of children with functional abdominal pain after 7 and 14 days of treatment.Results A total of 150 children were included,and after 1∶1 matching by propensity score matching method,60 cases in each group were included.The total effective rate of the observation group was higher than that of the control group(90.00%vs 73.33%),and the difference was statistically significant(P<0.05).After treatment,the levels of motilin and substance P in the two groups were significantly lower than those before treatment,and the levels of motilin and substance P,and in the observation group were lower than those in the control group(P<0.05).Repeated measurement ANOV

关 键 词：四联活菌片 神曲消食口服液 功能性腹痛 胃动素 P物质 

分 类 号：R985[医药卫生—药品] R725.7[医药卫生—药学]