不同剂量西甲硅油在胃镜检查中的祛泡效果比较  

Comparison of defoaming effects of different doses of simethicone during gastroscopy

作　　者：徐丽苹 于会生 刘进进 吕后宁 尚玛莉 刘红凌 于洪杰 司秋霞 XU Liping;YU Huisheng;LIU Jinjin;LYU Houning;SHANG Mali;LIU Hongling;YU Hongjie;SI Qiuxia(Digestive Endoscopy Center,Luoyang First People's Hospital,Henan Luoyang 471002,China)

机构地区：[1]洛阳市第一人民医院消化内镜中心,河南洛阳471002

出　　处：《临床药物治疗杂志》2024年第12期83-86,共4页Clinical Medication Journal

基　　金：中国消化道早癌医师共同成长计划科研项目(GTCZ-2021-HN-41-0001);洛阳市医疗卫生指导性科技计划项目(2022033Y);河南省医学科技攻关计划联合共建项目(LHGJ20230803)。

摘　　要：目的探讨口服不同剂量西甲硅油在胃镜检查中的祛泡效果,以确定西甲硅油的最佳应用剂量。方法选取2023年5—9月洛阳市第一人民医院行胃镜检查的门诊及住院患者为研究对象,按照随机数字表法根据西甲硅油的不同口服剂量将患者分为5组,即西甲硅油40、80、120、160、200 mg组。患者在胃镜检查前用2.5%碳酸氢钠的灭菌注射用水将西甲硅油乳剂稀释后口服,记录胃镜视野清晰度级别,比较不同剂量西甲硅油的祛泡效果。结果共纳入910例患者。口服西甲硅油后胃镜视野清晰度A级占比分别为40 mg组50.0%(63/126)、80 mg组62.7%(136/217)、120 mg组53.9%(118/219)、160 mg组48.6%(85/175)、200 mg组50.9%(88/173)。西甲硅油80 mg组的祛泡效果最佳,胃镜视野清晰度A级占比与40、160、200 mg组比较,差异均有统计学意义(P<0.05),但与西甲硅油120 mg组比较,差异无统计学意义(P>0.05)。各组患者不良反应发生率比较,差异均无统计学意义(P>0.05)。结论胃镜检查前口服小剂量西甲硅油有显著祛泡作用,可以达到满意的观察及诊断效果。采用80、120 mg西甲硅油时效果最佳,增加剂量不能提高祛泡效果。Objective To compare the defoaming effects of different doses of oral simethicone emulsion during gastroscopy and determine its optimal dosage.Methods Outpatients and inpatients undergoing gastroscopy at Luoyang First People's Hospital from May to September 2023 were randomly divided into 5 groups according to the dosage of simethicone emulsion:40,80,120,160 and 200 mg.Simethicone emulsion was diluted with 2.5%sterile sodium bicarbonate solution and administered orally.The clarity of the gastroscopic field was recorded and compared to assess the defoaming effects of the different doses.Results A total of 910 patients were included.The proportion of gastroscopic visual field clarity scored grade A after oral simethicone emulsion was as follows:50.0%(63/126)in the 40 mg group,62.7%(136/217)in the 80 mg group,53.9%(118/219)in the 120 mg group,48.6%(85/175)in the 160 mg group,50.9%(88/173)in the 200 mg group.The 80 mg group showed the best defoaming effect with statistically significant differences compared to 40 mg,160 mg and 200 mg groups(P<0.05)without significant difference compared to the 120 mg group(P>0.05).There was no significant difference in the incidence of adverse reactions among all groups(P>0.05).Conclusion Oral administration of low doses of simethicone emulsion before gastroscopy has a significant defoaming effect,providing satisfactory visualization and diagnostic accuracy.The optimal doses are 80 and 120 mg and increasing the dose beyond this does not improve defoaming efficacy.

关 键 词：西甲硅油 剂量 胃镜检查 祛泡 

分 类 号：R969.3[医药卫生—药理学] R573[医药卫生—药学]