针刺联合调神安眠方治疗肿瘤相关性失眠的临床疗效研究  

Study on the Clinical Efficacy of Acupuncture Combined with Tiaoshen Anmian Formula in the Treatment of Cancer-Related Insomnia

作　　者：曹少从 卢建荣 童亮 彭涛 CAO Shaocong;LU Jianrong;TONG Liang;PENG Tao(Department of Oncology,Shenzhen Futian Hospital of Guangzhou University of Chinese Medicine,Shenzhen 518034 Guangdong,China;Shenzhen Medical Center of Traditional Chinese Medicine Oncology,Shenzhen 518034 Guangdong,China)

机构地区：[1]广州中医药大学深圳医院(福田)肿瘤科,广东深圳518034 [2]深圳市中医肿瘤医学中心,广东深圳518034

出　　处：《中医肿瘤学杂志》2025年第1期25-31,共7页Journal of Oncology in Chinese Medicine

基　　金：深圳市医疗卫生三名工程项目资助(编号:SZZYSM202311011)。

摘　　要：目的观察针刺联合调神安眠方治疗肿瘤相关性失眠的疗效及对炎症反应和生活质量、中医症状积分的影响。方法本研究采用回顾性研究方法,研究纳入2021年1月~2022年12月在广州中医药大学深圳医院治疗的80例肿瘤相关性失眠患者,根据患者治疗方式的不同分为观察组40例和对照组40例。对照组为口服艾司唑仑治疗,观察组在此基础上加用针刺和调神安眠方治疗,两组均治疗4周。观察两组患者治疗前后5-羟色胺(5-hydroxytryptamine,5-HT)、多巴胺(dopamine,DA)、白细胞介素-1β(interleukin-1β,IL-1β)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素-6(interleukin-6,IL-6)和匹兹堡睡眠质量指数量表(pittsburgh sleep quality index,PSQI)、汉密顿焦虑量表(Hamilton anxiety scale,HAMA)、汉密顿抑郁量表(Hamilton depression scale,HAMD)评分、生活质量评分(SF-36评分)及中医症状积分变化,比较两组临床治疗效果,并记录不良反应发生情况。结果治疗后,两组患者DA、IL-1β、IL-6、TNF-α水平和PSQI评分、HAMA评分、HAMD评分、中医症状积分均明显低于治疗前(P均<0.05),且观察组上述指标均明显低于对照组(P均<0.05);两组患者5-HT水平和SF-36评分明显高于治疗前(P均<0.05),且观察组上述指标均明显高于对照组(P均<0.05)。对照组和观察组总有效率分别为62.46%(25/40)、87.47%(35/40),两组比较差异有统计学意义(P<0.05)。两组患者均未出现严重不良反应。结论针刺联合调神安眠方治疗肿瘤相关性失眠临床疗效显著、安全性高,可有效改善患者神经递质水平和生活质量、失眠相关症状,其机制可能与机体炎症反应有关。Objective To observe the therapeutic effect of acupuncture combined with Tiaoshen Anmian Formula on cancer-related insomnia and its impact on inflammatory response,quality of life,and traditional Chinese medicine(TCM)symptom score.Methods This study adopted a retrospective research method and included 80 patients with cancer-related insomnia who were treated at Shenzhen Hospital of Guangzhou University of Traditional Chinese Medicine from January 2021 to December 2022 were randomly divided into an observation group of 40 cases and a control group of 40 cases according to the different treatment methods of the patients.The control group was treated with oral estazolam,while the observation group was treated with acupuncture and Tiaoshen Anmian Formula on this basis of the control group treatment.Both groups were treated for 4 weeks.The levels of 5-hydroxytryptamine(5-HT),dopamine(DA),interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),and the scores of pittsburgh sleep quality index(PSQI),Hamilton anxiety scale(HAMA),Hamilton depression scale(HAMD),quality of life(SF-36),and traditional Chinese medicine(TCM)symptoms in the two groups of patients before and after treatment were observed.The efficacy of clinical treatments between the two groups was compared,and the occurrences of adverse reactions were recorded.Results After treatment,the levels of DA,IL-1β,IL-6,and TNF-α,and the scores of PSQI,HAMA,HAMD,and TCM symptoms in both groups of patients were significantly lower than those before treatment(all P<0.05),and the above indicators in the observation group were significantly lower than those in the control group(all P<0.05).The 5-HT levels and SF-36 scores of the two groups of patients were significantly higher than those before treatment(all P<0.05),and the above indicators in the observation group were significantly higher than those in the control group(all P<0.05).The total effective rates of the control group and the observation group were 62.46%(25/40)and 87.47%(35/40),respectiv

关 键 词：针刺 调神安眠方 艾司唑仑 肿瘤相关性失眠 炎症 生活质量 中医症状 

分 类 号：R273[医药卫生—中西医结合] R245[医药卫生—中医肿瘤科] R730.6[医药卫生—中医学]