姜黄素对肝损伤的改善作用及其机制研究进展  

Research progress in the effect of curcumin against liver injury and the underlying mechanisms

作　　者：张文君[1] 夏江 王昊 杨硕[1] 刘婷 朱婷 ZHANG Wenjun;XIA Jiang;WANG Hao;YANG Shuo;LIU Ting;ZHU Ting(College of Pharmacy,Harbin University of Commerce,Heilongjiang Harbin 150076,China;Pharmaceutical Engineering Technology Research Center,Harbin University of Commerce,Heilongjiang Harbin 150076,China)

机构地区：[1]哈尔滨商业大学药学院,黑龙江哈尔滨150076 [2]哈尔滨商业大学药物工程技术研究中心,黑龙江哈尔滨150076

出　　处：《中国医院药学杂志》2025年第1期99-107,共9页Chinese Journal of Hospital Pharmacy

基　　金：2023年度新一轮黑龙江省“双一流”学科协同创新成果项目(编号:LJGXCG2023-101);黑龙江省中医药管理局中医药经典普及化专项课题项目(编号:ZYW2024-076)。

摘　　要：姜黄素是从姜黄属植物根茎中提取的一种具有丰富生物活性的多酚类天然化合物。该文综述了近年来国内外关于姜黄素治疗不同类型肝损伤的实验研究,探讨了其保肝作用及相关机制。以实验动物肝损伤模型为基础,总结了姜黄素在化学性、药物性、酒精性、非酒精性和免疫性诱导的肝损伤模型中的治疗作用,并分析了其改善实验性肝损伤的机制,为深入研究姜黄素在肝损伤保护中的作用提供了参考。Curcumin is a natural polyphenolic extracted from the rhizome of turmeric with diverse biological activities.This paper reviewed the experimental studies on curcumin in the treatment of different types of liver injury at home and abroad in recent years,and discussed its hepatoprotective effect and underlying mechanisms.Based on the experimental animal models of liver injury,the therapeutic effects of curcumin in chemical,drug,alcoholic,non-alcoholic and immune-induced liver injury models were summarized,and the mechanism in improving experimental liver injury was assessed.We aim to provide a reference for the further study of curcumin in the protection of liver injury.

关 键 词：姜黄素 肝损伤 抗炎 抗氧化 作用机制 

分 类 号：R963[医药卫生—微生物与生化药学]