丹红注射液联合丁苯酞注射液治疗急性脑梗死的疗效及安全性分析  

Efficacy and Safety Analysis of Danhong Injection Combined with Butylphthalein Injection in the Treatment of Acute Cerebral Infarction

作　　者：张慧[1] 李泉 焦恒 程玉 于龙 ZHANG Hui;LI Quan;JIAO Heng;CHENG Yu;YU Long(Shangqiu First People's Hospital,Shangqiu 476100,Henan Province,China;The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan Province,China)

机构地区：[1]商丘市第一人民医院,河南商丘476100 [2]郑州大学第一附属医院,河南郑州450052

出　　处：《罕少疾病杂志》2025年第2期29-31,共3页Journal of Rare and Uncommon Diseases

基　　金：国家自然青年科学基金项目(82001252)。

摘　　要：目的分析丹红注射液与丁苯酞注射液联合用药方案治疗急性脑梗死的疗效及安全性。方法选取我院2021年8月至2023年7月期间收治的120例急性脑梗死患者作为研究对象,采用随机数字表法将患者分为参照组与实验组,每组60例。参照组丁苯酞注射液治疗,实验组丹红注射液联合丁苯酞注射液治疗。比较两组治疗前后生长因子水平、氧化应激指标、血液流变学指标、疗效及不良反应。结果治疗后,实验组生长因子水平高于参照组,血清氧化应激指标、血液流变学指标改善效果优于参照组,P<0.05。实验组治疗总有效率98.33%,高于参照组的86.67%,P<0.05;实验组不良反应发生率5.00%,与参照组的6.67%比较,差异无统计学意义,P>0.05。结论在急性脑梗死治疗中,丹红注射液联合丁苯酞注射液治疗能够更有效促进神经修复与血管再生,并减轻氧化应激损伤,改善血液循环,减少血栓形成风险,从而显著提高临床疗效,且不会增加不良反应,值得推广。Objective To analyze the efficacy and safety of Danhong injection combined with butylphthalein injection in the treatment of acute cerebral infarction.MethodsA total of 120 patients with acute cerebral infarction admitted to our hospital from August 2021 to July 2023 were selected as research objects,and the patients were divided into reference group and experimental group by random number table method,with 60 cases in each group.The reference group was treated with butylphthalein injection,and the experimental group was treated with Danhong injection combined with butylphthalein injection.Growth factor level,oxidative stress index,hemorheology index,efficacy and adverse reactions were compared between the two groups before and after treatment.ResultsAfter treatment,the growth factor level of experimental group was higher than that of reference group,and the improvement effect of serum oxidative stress index and hemorheology index was better than that of reference group,P<0.05.The total effective rate of the experimental group was 98.33%,higher than that of the reference group(86.67%),P<0.05;The incidence of adverse reactions in the experimental group was 5.00%,compared with 6.67%in the reference group,there was no statistical significance(P>0.05).ConclusionIn the treatment of acute cerebral infarction,Danhong injection combined with butylphthalein injection can more effectively promote nerve repair and vascular regeneration,reduce oxidative stress damage,improve blood circulation,and reduce the risk of thrombosis,so as to significantly improve clinical efficacy without increasing adverse reactions,which is worthy of promotion.

关 键 词：丹红注射液 丁苯酞注射液 急性脑梗死 生长因子水平 氧化应激指标 血液流变学指标 疗效 

分 类 号：R651.1[医药卫生—外科学]