慢性心力衰竭血清肌钙蛋白Ⅰ、肌红蛋白、N末端脑钠肽前体水平变化及其临床意义  

Chronic Heart Failure Patients Serum Troponin I and Myoglobin,N Terminal Brain Natriuretic Peptide Precursor Level Change and Its Clinical Significance

作　　者：杨亚慧 YANG Ya-hui(Department of Clinical Laboratory,the Second People's Hospital of Henan Province,Zhengzhou 451191,Henan Province,China)

机构地区：[1]河南省第二人民医院检验科,河南郑州451191

出　　处：《罕少疾病杂志》2025年第2期67-68,72,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的 分析慢性心力衰竭患者血清肌钙蛋白I(cTnI)、肌红蛋白(MYO)、血浆N末端脑钠肽前体(NT-pro BNP)水平变化及其临床意义。方法 选取2021年1月至2021年12月在本院确诊的86例慢性心力衰竭患者为慢性心衰组,同期选择在本院接受体检的30例健康人群作为健康组,对两组研究对象血清cTnI、Mb和NT-pro BNP水平进行测定,Spearman相关性分析血清指标与心功能分级的相关性。结果 慢性心衰组患者的cTnI、MYO和NT-pro BNP水平均高于健康组,差异均有统计学意义(P<0.05)。慢性心衰组患者中不同心功能分级患者的cTnI、MYO和NT-pro BNP水平指标比较,差异均有统计学意义(P<0.05)。Spearman相关性分析显示:慢性心衰组患者的cTnI、MYO和NT-pro BNP水平和其心功能分级呈正相关(r=0.451,0.432,0.487,P<0.05)。结论 慢性心力衰竭患者的cTnI、MYO和NT-pro BNP水平指标较健康人群明显升高,且其水平会随着心功能分级的升高而升高,临床可以通过检测以上指标水平来评估患者病情进展。Objective To analyze the changes of serum troponin I(cTnI),myoglobin(MYO)and plasma N-terminal brain natriuretic peptide precursor(NT-proBNP)levels and their clinical significance in patients with chronic heart failure.Methods A total of 86 patients with chronic heart failure diagnosed in our hospital from January 2021 to December 2021 were selected as the chronic heart failure group.During the same period,30 healthy people who underwent physical examinations in our hospital were selected as the healthy group.Serum cTnI,Mb and NT-proBNP levels of the two groups of subjects were measured.Spearman correlation analysis of serum indexes and cardiac function grading.Results The levels of cTnI,MYO and NT-proBNP in chronic heart failure group were higher than those in healthy group,the differences were statistically significant(P<0.05).There were statistically significant differences in cTnI,MYO and NT-proBNP levels among patients with different cardiac function grades in chronic heart failure group(P<0.05).Spearman correlation analysis showed that the levels of cTnI,MYO and NT-proBNP in patients with chronic heart failure group were positively correlated with their cardiac function grades(r=0.451,0.432,0.487,P<0.05).Conclusion The levels of cTnI,MYO and NT-proBNP in patients with chronic heart failure are significantly higher than those in healthy people,and their levels will increase with the increase of cardiac function grade.The above levels can be used to evaluate the progression of patients'disease.

关 键 词：慢性心力衰竭 肌钙蛋白Ⅰ 肌红蛋白 N末端脑钠肽前体 

分 类 号：R541.61[医药卫生—心血管疾病]