美托洛尔联合新活素治疗急性心力衰竭对血清心脏功能指标及超声心功指标的影响  

Effect of Metoprolol Combined with Neoactive on Serum Cardiac Function Index and Ultrasonic Cardiac Function Index in Patients with Acute Heart Failure

作　　者：付龙 宋诗源 屠淑敏[1] 苏敏 FU Long;SONG Shi-yuan;TU Shu-min;SU Min(Shangqiu First People's Hospital,Shangqiu 476100,Henan Province,China;The Second Affiliated Hospital of Shenyang Medical College,Shenyang 110002,Liaoning Province,China)

机构地区：[1]商丘市第一人民医院,河南商丘476100 [2]沈阳医学院附属第二医院,辽宁沈阳110002

出　　处：《罕少疾病杂志》2025年第2期79-81,共3页Journal of Rare and Uncommon Diseases

基　　金：国家自然青年科学基金项目(82100317)。

摘　　要：目的 研究美托洛尔与新活素联合使用对急性心力衰竭(AHF)治疗效果的影响。方法 本研究选取2021年5月起,至2023年5月为止,本院收治的92名AHH患者作为研究对象。利用随机数字表分配方法,将患者随机分为两组,每组46名,一组作为对照组,另一组作为实验组。所有患者均予以常规抗感染、利尿剂及扩张血管治疗,参照组在此基础上采用美托洛尔治疗,研究组在对照组基础上加用新活素治疗,两组均持续治疗10d。观察两组临床疗效、血清心脏功能指标、超声心功能指标及不良反应发生情况。结果 研究组总治疗有效率高于参照组(P<0.05);两组治疗后的血清脑钠肽(BNP)及肌钙蛋白I(cTnI)水平均低于治疗前,且研究组低于参照组(P<0.05);两组治疗后的左室射血分数(LVEF)水平均高于治疗前,左室收缩末期内径(LVESD)以及左室舒张末期内径(LVEDD)水平均低于治疗前,且研究组LVEF水平高于参照组,LVESD及LVEDD水平均低于参照组(P<0.05);两组不良反应总发生率无显著差异(P>0.05)。结论 美托洛尔联合新活素治疗急性心力衰竭的疗效显著,有助于改善患者心功能水平,且不会增加不良反应。Objective To investigate the effect of metoprolol combined with neoactive in the treatment of acute heart failure.Methods 92 cases of acute heart failure admitted to our hospital from May 2021 to May 2023 were divided into the reference group and the study group with 46 cases each according to random number table method.All patients were treated with routine anti-infection,diuretic and vasodilator.The reference group was treated with metoprool on the basis of this treatment,and the study group was treated with neoactive on the basis of the control group.Both groups were treated for 10 days.The clinical efficacy,serum cardiac function index,ultrasound cardiac function index and the occurrence of adverse reactions were observed.Results The total effective rate of the study group was higher than that of the reference group(P<0.05).The levels of serum BNP and cTnI in two groups after treatment were lower than before treatment,and the study group was lower than the reference group(P<0.05).LVEF levels after treatment were higher than before treatment,LVESD and LVEDD levels were lower than before treatment,LVEF levels in study group were higher than reference group,LVESD and LVEDD levels were lower than reference group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Metoprolol combined with neoactin is effective in the treatment of acute heart failure,which can help to improve the level of cardiac function without increasing adverse reactions.

关 键 词：美托洛尔 新活素 急性心力衰竭(AHF) 心功能 

分 类 号：R541.6[医药卫生—心血管疾病]