益气解毒通络方联合恩替卡韦治疗失代偿期乙型肝炎肝硬化的疗效及对肝功能的影响  

Therapeutic Efficacy and Effect on Liver Function of Yiqi Detoxification and Tongluo Formula Combined with Entecavir in the Treatment of Cirrhotic Patients with Decompensated Hepatitis B

作　　者：吴萌萌 宋爱军[1] WU Meng-meng;SONG Ai-jun(Department of Integrated Traditional Chinese and Western Medicine,The Fifth People's Hospital of Anyang,Anyang 455000,Henan Province,China)

机构地区：[1]安阳市第五人民医院中西医结合科,河南安阳455000

出　　处：《罕少疾病杂志》2025年第2期92-94,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的 探究益气解毒通络方联合恩替卡韦治疗失代偿期乙型肝炎肝硬化患者的疗效及对肝功能的影响。方法 选取2017年至2022年于本院接受治疗的失代偿期乙型肝炎肝硬化患者87例,按治疗方案分组,仅采用恩替卡韦治疗的47例病人为对照组,在对照组基础上,联用益气解毒通络方进行治疗的40例病人为观察组。比较两组的临床疗效、肝功能指标、肝纤维化程度以及病毒载量。结果 两组治疗前各指标无显著性差异(P>0.05)。治疗后,与对照组相比,观察组治疗总有效率、ALB水平均显著升高(P<0.05);ALT、TBIL、肝脏硬度值以及HBV DNA水平均显著降低(P<0.05)。结论 益气解毒通络方联合恩替卡韦治疗失代偿期乙型肝炎肝硬化患者,具有较好的临床疗效,能有效改善患者的肝功能,明显降低肝纤维化程度及病毒载量,值得临床推广。Objective To investigate the efficacy and effect on liver function of Yiqi detoxification and Tongluo formula combined with entecavir in the treatment of cirrhotic patients with decompensated hepatitis B.Methods 87 patients with decompensated hepatitis B cirrhosis who were treated in our hospital from 2017 to 2022 were selected and grouped according to treatment regimen,47 patients who were treated with entecavir only were the control group,and 40 patients who were treated with Yiqi Detoxification and Tongluo Formula on the basis of the control group were the observation group.The clinical efficacy,liver function indexes,degree of liver fibrosis and viral load of the two groups were compared.Results There was no significant difference between the two groups of pretreatment indicators(P>0.05).After treatment,the total efficacy and ALB levels were significantly higher in the observation group(P<0.05),ALT,TBIL,liver hardness value and HBV DNA level were significantly lower(P<0.05).Conclusion Yiqi Jiedu Tongluo recipe combined with entecavir has a good clinical effect on patients with decompensated hepatitis B cirrhosis,which can effectively improve patients'liver function,significantly reduce the degree of liver fibrosis and viral load,and is worthy of clinical promotion.

关 键 词：益气解毒.通络方 恩替卡韦 失代偿期 乙型肝炎肝硬化 疗效 肝功能 

分 类 号：R512.62[医药卫生—内科学]