干扰素联合聚甲酚磺醛治疗高危型HPV33阳性宫颈炎的临床研究  

Clinical Study of Interferon Combined with Polycresol Sulfonal in the Treatment of High-risk Patients with HPV33 Positive Cervicitis

作　　者：杜晓敏 余黎吉 DU Xiao-min;YU Li-ji(Department of Gynaecology,Quanzhou First Hospital,Quanzhou 362011,Fujian Province,China)

机构地区：[1]泉州市第一医院妇科,福建泉州362011

出　　处：《罕少疾病杂志》2025年第2期114-116,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的探讨干扰素联合聚甲酚磺醛治疗高危型人乳头瘤病毒(HPV)33阳性宫颈炎患者的临床效果。方法选取2021年4月至2023年4月泉州市第一医院诊治的高危型HPV33阳性宫颈炎患者100例,按照随机数字表法分为对照组(聚甲酚磺醛治疗)50例,观察组(干扰素+聚甲酚磺醛治疗)50例,对比两组炎性因子水平、阴道内环境指标、HPV病毒载量和HPV转阴情况。结果治疗8周后观察组白介素-2(IL-2)、白介素-17(IL-17)、肿瘤坏死因子(TNF-α)水平低于对照组;观察组阴道pH值低于对照组,乳酸菌活菌数量和阴道健康评分优于对照组;观察组HPV病毒载量低于对照组,HPV转阴率高于对照组转阴率(P均<0.05);观察组不良反应发生率对照组比较无显著差异(P>0.05)。结论干扰素联合聚甲酚磺醛能够有效改善阴道内环境,安全性较高,不良反应发生率较低,有利于高危型HPV33阳性宫颈炎患者转阴。Objective To explore the clinical effect of combining interferon with polycresol aldehyde in patients with high-risk human papillomavirus(HPV)33-positive cervicitis.Methods A total of 100 high-risk HPV33-positive cervectitis patients diagnosed and treated in Quanzhou First Hospital from April 2021 to April 2023 were selected and divided into control group(50 cases treated with polycresol sulfonal)and observation group(50 cases treated with interferon+polycresol sulfonal)according to random number table method.The levels of inflammatory factors,vaginal environmental indicators,HPV viral load and HPV negative conversion were compared between the two groups.Results After 8 weeks of treatment,the levels of interleukin-2(IL-2),interleukin-17(IL-17)and tumor necrosis factor(TNF-α)in observation group were lower than those in control group.The vaginal pH value of observation group was lower than that of control group,the number of viable lactic acid bacteria and vaginal health score were better than that of control group.HPV viral load in observation group was lower than that in control group,and HPV negative conversion rate was higher than that in control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the observation group and the control group(P>0.05).Conclusion Interferon combined with polycresol sulfonal can effectively improve the vaginal environment,with high safety and low incidence of adverse reactions,which is conducive to the negative conversion of high-risk HPV33 positive cervicitis patients.

关 键 词：干扰素 聚甲酚磺醛 高危型HPV33 宫颈炎 

分 类 号：R711.32[医药卫生—妇产科学]