维生素D联合拉贝洛尔对妊娠期高血压疾病血清AngⅡ、NO水平的影响  

Effects of Vitamin D Combined with Labetalol on Serum AngII and NO in Patients with Gestational Hypertension

作　　者：张婧喆 刘菲 程存 ZHANG Jing-zhe;LIU Fei;CHENG Cun(Department of Gynecology and Obstetrics,Nanyang Central Hospital,Nanyang 473000,Henan Province,China)

机构地区：[1]南阳市中心医院妇产科,河南南阳473000

出　　处：《罕少疾病杂志》2025年第2期159-160,共2页Journal of Rare and Uncommon Diseases

摘　　要：目的 探究维生素D联合拉贝洛尔对妊娠期高血压疾病患者血清血管紧张素Ⅱ(AngⅡ)、一氧化氮(NO)水平的影响。方法 选取本院于2022年1月至2023年12月收治的380例妊娠期高血压患者,按照随机数字表法分为单一组(n=190)和联合组(n=190),两组均采用硫酸镁行基础治疗,单一组予以拉贝洛尔治疗,联合组在单一组基础上联合维生素D治疗。评估两组临床疗效,并分别于治疗前后,检测并对比血清学标志物[超敏C反应蛋白(hs-CRP)、AngⅡ],血浆NO、内皮素-1(ET-1)、血清尿素氮(BUN)、尿酸(UA)水平变化情况。观察并记录两组治疗期间不良反应发生情况。结果 联合组治疗总有效率95.26%高于单一组的89.48%(P<0.05);治疗后,联合组hs-CRP、AngⅡ、ET-1、BUN、UA水平均低于单一组,NO水平高于单一组(P<0.05);两组不良反应发生率无明显差异(P>0.05)。结论 维生素D联合拉贝洛尔治疗妊娠期高血压疾病患者效果良好,可通过降低AngⅡ水平,提高NO水平缓解症状,促进康复。Objective To explore the effects of vitamin D combined with labetalol on serum angiotensin II(AngII)and nitric oxide(NO)in patients with gestational hypertension.Methods A total of 380 patients with gestational hypertension admitted to the hospital were enrolled between January 2022 and December 2023.According to random number table method,they were divided into single group(n=190)and combination group(n=190).On basis of basic treatment with magnesium sulfate,single group was treated with labetalol,while combination group was treated with vitamin D on basis of single group.The clinical curative effect in the two groups was evaluated.The changes in serological markers[hypersensitive C-reactive protein(hs-CRP),AngII],plasma NO,endothelin-1(ET-1),blood urea nitrogen(BUN)and uric acid(UA)before and after treatment were detected and compared.The occurrence of adverse reactions during treatment was observed and recorded.Results The total response rate of treatment in combination group was higher than that in single group(95.26%vs 89.48%,P<0.05).After treatment,levels of hs-CRP,AngII,ET-1,BUN and UA in combination group were lower than those in single group,while NO was higher than that in single group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The curative effect of vitamin D combined with labetalol is good in patients with gestational hypertension,which can relieve symptoms and promote rehabilitation by decreasing AngII level and increasing NO level.

关 键 词：维生素D 拉贝洛尔 妊娠期高血压 血清血管紧张素Ⅱ 一氧化氮 

分 类 号：R977.24[医药卫生—药品]